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Review
. 2015 Aug 27;162(5):944-7.
doi: 10.1016/j.cell.2015.08.006.

Not All DDRs Are Created Equal: Non-Canonical DNA Damage Responses

Rebecca C Burgess  1 , Tom Misteli  2
Affiliations
Review

Not All DDRs Are Created Equal: Non-Canonical DNA Damage Responses

Rebecca C Burgess et al. Cell. .

Abstract

It is commonly assumed that there is a single canonical DNA damage response (DDR) that protects cells from various types of double-strand breaks and that its activation occurs via recognition of DNA ends by the DDR machinery. Recent work suggests that both assumptions may be oversimplifications. Here, we discuss several variations of the DDR in which the pathway is activated by diverse cellular events and/or generates distinct signaling outcomes. The existence of multiple non-canonical DDRs provides insights into how DNA damage is sensed and suggests a highly modular organization of the DDR.

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Figures

Figure 1
Figure 1
Modular structure of canonical and non-canonical DDRs. Stimuli are in red: damage stimuli, boxes; non-damage stimuli, text. Sensors (yellow) lead to activation of various transmission modules (blue boxes) and downstream effectors (green), each of which can be disengaged for different DDR outcomes.
See this image and copyright information in PMC

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