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Review
. 2015 Nov 1;309(9):L915-23.
doi: 10.1152/ajplung.00266.2015. Epub 2015 Aug 28.

Platelets in the pathogenesis of acute respiratory distress syndrome

Hemang Yadav  1 , Daryl J Kor  2
Affiliations
Review

Platelets in the pathogenesis of acute respiratory distress syndrome

Hemang Yadav et al. Am J Physiol Lung Cell Mol Physiol. .

Abstract

Platelets have an emerging and incompletely understood role in a myriad of host immune responses, extending their role well beyond regulating thrombosis. Acute respiratory distress syndrome is a complex disease process characterized by a range of pathophysiologic processes including oxidative stress, lung deformation, inflammation, and intravascular coagulation. The objective of this review is to summarize existing knowledge on platelets and their putative role in the development and resolution of lung injury.

Keywords: ALI; ARDS; aspirin; lung injury; platelet.

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Figures

Fig. 1.
Fig. 1.
Mechanisms by which platelets may contribute to the development and resolution of acute respiratory distress syndrome (ARDS). IL-6, interleukin-6; TNF, tumor necrosis factor; NF-кB, nuclear factor-к-light-chain-enhancer of activated B cells; ASA, aspirin; LXs, lipoxins; ATLs, aspirin-triggered lipoxins; HO-1, heme oxygenase-1; ICAM-1, intercellular adhesion molecule; CCL-5, chemokine (C-C motif) ligand-5; CXCL4, chemokine (C-X-C motif) ligand-4; vWF, von-Willebrand factor; NETs, neutrophil extracellular traps.
See this image and copyright information in PMC

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