Baseline characteristics of African Americans in the Systolic Blood Pressure Intervention Trial

Carolyn H Still¹, Timothy E Craven², Barry I Freedman³, Peter N Van Buren⁴, Kaycee M Sink⁵, Anthony A Killeen⁶, Jeffrey T Bates⁷, Alberta Bee⁸, Gabriel Contreras⁹, Suzanne Oparil¹⁰, Carolyn M Pedley¹¹, Barry M Wall¹², Suzanne White¹³, Delia M Woods¹⁴, Carlos J Rodriguez¹⁵, Jackson T Wright Jr¹⁶; SPRINT Study Research Group

Affiliations

¹ Division of Nephrology and Hypertension, Clinical Hypertension Program, University Hospitals Case Medical Center, Cleveland, OH, USA; Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA. Electronic address: cwh11@case.edu.
² Department of Biostatistics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
³ Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
⁴ Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
⁵ Wake Forest School of Medicine, Section on Geriatrics and Gerontology, Winston-Salem, NC, USA.
⁶ Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
⁷ Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA.
⁸ Division of Nephrology and Hypertension, Clinical Hypertension Program, University Hospitals Case Medical Center, Cleveland, OH, USA.
⁹ Nephrology Department, University of Miami Miller School of Medicine, Miami, FL, USA.
¹⁰ Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
¹¹ Department of Internal Medicine, Wake Forest School of Medicine, Wake Forest Baptist Health, Winston-Salem, NC, USA.
¹² Memphis Veterans Affairs Medical Center, Memphis, TN, USA.
¹³ Department of Internal Medicine, Northeast Ohio Neighborhood Health Services, Inc, Cleveland, OH, USA.
¹⁴ Department of Medicine, Nephrology Division, Vanderbilt University, Nashville, TN, USA.
¹⁵ Department of Epidemiology and Prevention, Section on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
¹⁶ Division of Nephrology and Hypertension, Clinical Hypertension Program, University Hospitals Case Medical Center, Cleveland, OH, USA; Department of Nephrology and Hypertension, Case Western Reserve University, School of Medicine, Cleveland, OH, USA.

PMID: 26320890
PMCID: PMC4573272
DOI: 10.1016/j.jash.2015.06.012

Baseline characteristics of African Americans in the Systolic Blood Pressure Intervention Trial

Carolyn H Still et al. J Am Soc Hypertens. 2015 Sep.

. 2015 Sep;9(9):670-9.

doi: 10.1016/j.jash.2015.06.012. Epub 2015 Aug 7.

Authors

Affiliations

¹ Division of Nephrology and Hypertension, Clinical Hypertension Program, University Hospitals Case Medical Center, Cleveland, OH, USA; Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA. Electronic address: cwh11@case.edu.
² Department of Biostatistics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
³ Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
⁴ Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
⁵ Wake Forest School of Medicine, Section on Geriatrics and Gerontology, Winston-Salem, NC, USA.
⁶ Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
⁷ Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA.
⁸ Division of Nephrology and Hypertension, Clinical Hypertension Program, University Hospitals Case Medical Center, Cleveland, OH, USA.
⁹ Nephrology Department, University of Miami Miller School of Medicine, Miami, FL, USA.
¹⁰ Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
¹¹ Department of Internal Medicine, Wake Forest School of Medicine, Wake Forest Baptist Health, Winston-Salem, NC, USA.
¹² Memphis Veterans Affairs Medical Center, Memphis, TN, USA.
¹³ Department of Internal Medicine, Northeast Ohio Neighborhood Health Services, Inc, Cleveland, OH, USA.
¹⁴ Department of Medicine, Nephrology Division, Vanderbilt University, Nashville, TN, USA.
¹⁵ Department of Epidemiology and Prevention, Section on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
¹⁶ Division of Nephrology and Hypertension, Clinical Hypertension Program, University Hospitals Case Medical Center, Cleveland, OH, USA; Department of Nephrology and Hypertension, Case Western Reserve University, School of Medicine, Cleveland, OH, USA.

PMID: 26320890
PMCID: PMC4573272
DOI: 10.1016/j.jash.2015.06.012

Abstract

The Systolic Blood Pressure Intervention Trial (SPRINT) will compare treatment to a systolic blood pressure goal of <120 mm Hg to treatment to the currently recommended goal of <140 mm Hg for effects on incident cardiovascular, renal, and neurologic outcomes including cognitive decline. The objectives of this analysis are to compare baseline characteristics of African American (AA) and non-AA SPRINT participants and explore factors associated with uncontrolled blood pressure (BP) by race. SPRINT enrolled 9361 hypertensive participants aged older than 50 years. This cross-sectional analysis examines sociodemographics, baseline characteristics, and study measures among AAs compared with non-AAs. AAs made up 31% of participants. AAs (compared with non-AAs) were younger and less frequently male, had less education, and were more likely uninsured or covered by Medicaid. In addition, AAs scored lower on the cognitive screening test when compared with non-AAs. Multivariate logistic regression analysis found BP control rates to <140/90 mm Hg were higher for AAs who were male, had higher number of chronic diseases, were on diuretic treatment, and had better medication adherence. SPRINT is well poised to examine the effects of systolic blood pressure targets on clinical outcomes as well as predictors influencing BP control in AAs.

Keywords: Cardiovascular disease; SPRINT; blacks; clinical trials; hypertension.

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Conflict of interest statement

Conflict of Interest: We have no conflicts of interest to disclose.

Comment in

Is there a bend in the upward trend of high blood pressure in childhood?: A commentary on prevalence of and trends in dyslipidemia and blood pressure among US children and adolescents, 1999-2012.
Falkner B. Falkner B. J Am Soc Hypertens. 2015 Sep;9(9):668-9. doi: 10.1016/j.jash.2015.07.003. Epub 2015 Jul 14. J Am Soc Hypertens. 2015. PMID: 26260425 No abstract available.
From the Editor.
Levy D. Levy D. J Am Soc Hypertens. 2015 Sep;9(9):661-2. doi: 10.1016/j.jash.2015.07.017. Epub 2015 Jul 31. J Am Soc Hypertens. 2015. PMID: 26369440 No abstract available.

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Baseline characteristics of African Americans in the Systolic Blood Pressure Intervention Trial

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Baseline characteristics of African Americans in the Systolic Blood Pressure Intervention Trial

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