Extracellular RNAs: development as biomarkers of human disease

Joseph F Quinn¹, Tushar Patel², David Wong³, Saumya Das⁴, Jane E Freedman⁵, Louise C Laurent⁶, Bob S Carter⁷, Fred Hochberg⁷, Kendall Van Keuren-Jensen⁸, Matt Huentelman⁸, Robert Spetzler⁹, M Yashar S Kalani⁹, Jorge Arango¹⁰, P David Adelson¹⁰, Howard L Weiner¹¹, Roopali Gandhi¹¹, Beatrice Goilav¹², Chaim Putterman¹³, Julie A Saugstad¹⁴

Affiliations

¹ Department of Neurology, Oregon Health & Science University, Portland, OR, USA; quinnj@ohsu.edu.
² Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.
³ School of Dentistry, Department of Head and Neck Surgery, University of California at Los Angeles, Los Angeles, CA, USA.
⁴ Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
⁵ Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
⁶ Department of Reproductive Medicine, University of California at San Diego, San Diego, CA, USA.
⁷ Department of Neurosurgery, University of California at San Diego, San Diego, CA, USA.
⁸ Translational Genomics Research Institute, Phoenix, AZ, USA.
⁹ Barrow Neurological Institute, Department of Neurological Surgery, St. Joseph's Hospital & Medical Center, Phoenix, AZ, USA.
¹⁰ Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA.
¹¹ Ann Romney Center for Neurologic Disease, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
¹² Division of Pediatric Nephrology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
¹³ Division of Rheumatology and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
¹⁴ Department of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, OR, USA; saugstad@ohsu.edu.

PMID: 26320940
PMCID: PMC4553262
DOI: 10.3402/jev.v4.27495

Extracellular RNAs: development as biomarkers of human disease

Joseph F Quinn et al. J Extracell Vesicles. 2015.

. 2015 Aug 28:4:27495.

doi: 10.3402/jev.v4.27495. eCollection 2015.

Authors

Affiliations

¹ Department of Neurology, Oregon Health & Science University, Portland, OR, USA; quinnj@ohsu.edu.
² Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.
³ School of Dentistry, Department of Head and Neck Surgery, University of California at Los Angeles, Los Angeles, CA, USA.
⁴ Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
⁵ Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
⁶ Department of Reproductive Medicine, University of California at San Diego, San Diego, CA, USA.
⁷ Department of Neurosurgery, University of California at San Diego, San Diego, CA, USA.
⁸ Translational Genomics Research Institute, Phoenix, AZ, USA.
⁹ Barrow Neurological Institute, Department of Neurological Surgery, St. Joseph's Hospital & Medical Center, Phoenix, AZ, USA.
¹⁰ Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA.
¹¹ Ann Romney Center for Neurologic Disease, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
¹² Division of Pediatric Nephrology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
¹³ Division of Rheumatology and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
¹⁴ Department of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, OR, USA; saugstad@ohsu.edu.

PMID: 26320940
PMCID: PMC4553262
DOI: 10.3402/jev.v4.27495

Abstract

Ten ongoing studies designed to test the possibility that extracellular RNAs may serve as biomarkers in human disease are described. These studies, funded by the NIH Common Fund Extracellular RNA Communication Program, examine diverse extracellular body fluids, including plasma, serum, urine and cerebrospinal fluid. The disorders studied include hepatic and gastric cancer, cardiovascular disease, chronic kidney disease, neurodegenerative disease, brain tumours, intracranial haemorrhage, multiple sclerosis and placental disorders. Progress to date and the plans for future studies are outlined.

Keywords: ERCC; biomarkers; exRNA; extracellular RNA.

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References

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Extracellular RNAs: development as biomarkers of human disease

Affiliations

Extracellular RNAs: development as biomarkers of human disease

Authors

Affiliations

Abstract

Figures

References

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