mRNA: Fulfilling the Promise of Gene Therapy
- PMID: 26321183
- PMCID: PMC4817894
- DOI: 10.1038/mt.2015.138
mRNA: Fulfilling the Promise of Gene Therapy
Comment on
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Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals.Mol Ther. 2015 Sep;23(9):1456-64. doi: 10.1038/mt.2015.103. Epub 2015 Jun 8. Mol Ther. 2015. PMID: 26050989 Free PMC article.
References
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- Sahin, U, Kariko, K and Tureci, O (2014). mRNA-based therapeutics––developing a new class of drugs. Nat Rev Drug Discov 13: 759–780. - PubMed
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- Jirikowski, GF, Sanna, PP, Maciejewski-Lenoir, D and Bloom, FE (1992). Reversal of diabetes insipidus in Brattleboro rats: intrahypothalamic injection of vasopressin mRNA. Science 255: 996–998. - PubMed
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- Karikó, K, Buckstein, M, Ni, H and Weissman, D (2005). Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23: 165–175. - PubMed
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