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Comment
. 2015 Sep;23(9):1420-2.
doi: 10.1038/mt.2015.140.

Hopx and the Cardiomyocyte Parentage

Michael D Schneider  1 , Andrew H Baker  2 , Paul Riley  3
Affiliations
Comment

Hopx and the Cardiomyocyte Parentage

Michael D Schneider et al. Mol Ther. 2015 Sep.
No abstract available

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Figures

Figure 1
Figure 1
Hopx in cardiac myogenesis. Hopx-expressing cells are derived from earlier Nkx2.5- and Isl1-specified cardiovascular progenitor cells, but give rise to cardiomyocytes selectively. Above: shown schematically, Hopx expression in the early heart (left) and the resulting distribution of Hopx-fated myocytes in adult myocardium (right). Below: sequential stages of cardiac myogenesis. The Hopx–Smad–Hdac complex links inductive BMPs to the termination of Wnt signals, as is necessary for cardiomyocyte formation. BMP, bone morphogenetic protein; LA, left atrium; LV, left ventricle; OFT, outflow tract; RA, right atrium; RV, right ventricle.
See this image and copyright information in PMC

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References

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