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. 2015 Aug 11:6:125.
doi: 10.3389/fendo.2015.00125. eCollection 2015.

Prevalence and Determinants of Glycemic Abnormalities in Cardiac Surgery Patients without a History of Diabetes: A Prospective Study

Roma Y Gianchandani  1 , Sima Saberi  2 , Preethi Patil  1 , Richard L Prager  3 , Rodica Pop-Busui  1
Affiliations

Prevalence and Determinants of Glycemic Abnormalities in Cardiac Surgery Patients without a History of Diabetes: A Prospective Study

Roma Y Gianchandani et al. Front Endocrinol (Lausanne). .

Abstract

Objective: To evaluate the prevalence and persistence of postoperative glycemic abnormalities in patients without a history of diabetes, undergoing cardiac surgery (CS).

Methods: Ninety-two patients without diabetes with planned elective CS procedures at a tertiary institution were evaluated preoperatively and 3 months postoperatively for measures of glucose control including hemoglobin A1c, fasting plasma glucose, 2-h post oral glucose load, and insulin levels. Data from the hospital course were recorded.

Results: Valid data were available from 61 participants at 3 months; 59% had prediabetes and 10% had diabetes preoperatively by one or more diagnostic criteria and continued to be dysglycemic at 3 months. Preoperative A1C was an independent predictor of postoperative hyperglycemia (p = 0.02). Insulin resistance and BMI rather than glycemic abnormalities before surgery were associated with a longer duration of the postoperative insulin infusion (p = 0.004, p = 0.048).

Conclusion: Seventy percent of CS patients without known diabetes met criteria for diabetes or prediabetes preoperatively, and these abnormalities persisted after surgery.

Keywords: A1c; cardiovascular surgery; diabetes mellitus; hyperglycemia; insulin resistance; prediabetes.

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