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Comment
. 2015 Sep;88(3):442-4.
doi: 10.1038/ki.2015.193.

Implications of the long interdialytic gap: a problem of excess accumulation vs. excess removal?

Connie M Rhee  1 , Kamyar Kalantar-Zadeh  1   2
Affiliations
Comment

Implications of the long interdialytic gap: a problem of excess accumulation vs. excess removal?

Connie M Rhee et al. Kidney Int. 2015 Sep.

Abstract

Evidence suggests that patients receiving intermittent maintenance hemodialysis treatments experience higher mortality the day after the long 2-day interdialytic gap. A new study confirms higher mortality and reports increased hospitalization immediately after the long interdialytic interval among incident hemodialysis patients in the United Kingdom. Larger fluid accumulation followed by excessive ultrafiltration and abrupt fluctuations in serum potassium concentrations may be among potential factors contributing to the morbidity and mortality of this precarious period.

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Figures

Figure 1
Figure 1
Schematic representation of the fluid and electrolyte (potassium, K) fluctuations during a theoretical thrice-weekly hemodialysis schedule of a patient who receives hemodialysis treatment on Monday, Wednesday and Friday.
See this image and copyright information in PMC

Comment on

References

    1. Mortality and hospitalisation rates associated with the long interdialytic gap in thrice-weekly haemodialysis patients. Kidney International. 2015;xx(xx):xx–xx. - PubMed
    1. Rhee CM, Unruh M, Chen J, et al. Infrequent dialysis: a new paradigm for hemodialysis initiation. Seminars in dialysis. 2013;26(6):720–7. Epub 2013/09/11. - PMC - PubMed
    1. Bleyer AJ, Russell GB, Satko SG. Sudden and cardiac death rates in hemodialysis patients. Kidney international. 1999;55(4):1553–9. Epub 1999/04/14. - PubMed
    1. Foley RN, Gilbertson DT, Murray T, et al. Long interdialytic interval and mortality among patients receiving hemodialysis. The New England journal of medicine. 2011;365(12):1099–107. Epub 2011/10/14. - PubMed
    1. Zhang H, Schaubel DE, Kalbfleisch JD, et al. Dialysis outcomes and analysis of practice patterns suggests the dialysis schedule affects day-of-week mortality. Kidney international. 2012;81(11):1108–15. Epub 2012/02/03. - PMC - PubMed

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