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. 1979:7 Suppl 5:116-24.

Mobilization of murine hemopoietic stem cells (HSC) by Pyran Copolymer

A R Zander, K A Dicke, D Verma, S Ginzbarg, G Spitzer
  • PMID: 263238

Mobilization of murine hemopoietic stem cells (HSC) by Pyran Copolymer

A R Zander et al. Exp Hematol. 1979.

Abstract

Pyran Copolymer, divinyl-ether maleic anhydride increases the concentration of circulating pluripotential stem cells in mice by a factor of 15 to 30. Maximal mobilization occurs five days after Pyran Copolymer injection with synchronous peaks of CFU-S and CFU-C. When Pyran fractions of defined molecular weight from 12,000 to 52,000 are injected into mice, mobilization of CFU-S and CFU-C parallels molecular weight. Hemopoietic stem cells are mobilized from bone marrow into peripheral blood and subsequently trapped in the spleen.

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