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Comment
. 2015 Oct;12(10):558-9.
doi: 10.1038/nrgastro.2015.152. Epub 2015 Sep 1.

Hepatitis: Epigenetic control of HBV by HBx protein--releasing the break?

Ulrike Protzer  1
Affiliations
Comment

Hepatitis: Epigenetic control of HBV by HBx protein--releasing the break?

Ulrike Protzer. Nat Rev Gastroenterol Hepatol. 2015 Oct.

Abstract

HBV persists by depositing covalently closed circular DNA (cccDNA) into the nucleus of infected host cells. HBV X protein (HBx) is a crucial determinant for regulating HBV activity, but the molecular details have not been fully understood. A new role for HBx in regulating cccDNA transcription has now been identified.

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