Review
doi: 10.3892/or.2015.4227.
Epub 2015 Aug 26.
Regulation mechanism of Fbxw7-related signaling pathways (Review)
Affiliations
- PMID: 26324296
- DOI: 10.3892/or.2015.4227
Item in Clipboard
Review
Regulation mechanism of Fbxw7-related signaling pathways (Review)
Oncol Rep.
2015 Nov.
Abstract
F-box and WD repeat domain-containing 7 (Fbxw7), the substrate-recognition component of SCFFbxw7 complex, is thought to be a tumor suppressor involved in cell growth, proliferation, differentiation and survival. Although an increasing number of ubiquitin substrates of Fbxw7 have been identified, the best characterized substrates are cyclin E and c-Myc. Fbxw7/cyclin E and Fbxw7/c-Myc pathways are tightly regulated by multiple regulators. Fbxw7 has been identified as a tumor suppressor in hepatocellular carcinoma. This review focused on the regulation of Fbxw7/cyclin E and Fbxw7/c-Myc pathways and discussed findings to gain a better understanding of the role of Fbxw7 in hepatocellular carcinoma.
Similar articles
-
Recombinant human adenovirus-p53 injection induced apoptosis in hepatocellular carcinoma cell lines mediated by p53-Fbxw7 pathway, which controls c-Myc and cyclin E.PLoS One. 2013 Jul 1;8(7):e68574. doi: 10.1371/journal.pone.0068574. Print 2013. PLoS One. 2013. Retraction in: PLoS One. 2020 Mar 27;15(3):e0231287. doi: 10.1371/journal.pone.0231287. PMID: 23840897 Free PMC article. Retracted.
-
FBXW7 acts as an independent prognostic marker and inhibits tumor growth in human osteosarcoma.Int J Mol Sci. 2015 Jan 22;16(2):2294-306. doi: 10.3390/ijms16022294. Int J Mol Sci. 2015. PMID: 25622249 Free PMC article.
-
Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells.Biochem Biophys Res Commun. 2012 Feb 10;418(2):426-32. doi: 10.1016/j.bbrc.2012.01.054. Epub 2012 Jan 20. Biochem Biophys Res Commun. 2012. PMID: 22285861 Free PMC article.
-
[Function and mechanism of tumor suppressor gene FBW7 in tumorigenesis].Zhonghua Bing Li Xue Za Zhi. 2013 Mar;42(3):214-6. doi: 10.3760/cma.j.issn.0529-5807.2013.03.020. Zhonghua Bing Li Xue Za Zhi. 2013. PMID: 23769449 Review. Chinese. No abstract available.
-
Fbxw7 Tumor Suppressor: A Vital Regulator Contributes to Human Tumorigenesis.Medicine (Baltimore). 2016 Feb;95(7):e2496. doi: 10.1097/MD.0000000000002496. Medicine (Baltimore). 2016. PMID: 26886596 Free PMC article. Review.
Cited by
-
New Challenges in Tumor Mutation Heterogeneity in Advanced Ovarian Cancer by a Targeted Next-Generation Sequencing (NGS) Approach.Cells. 2019 Jun 14;8(6):584. doi: 10.3390/cells8060584. Cells. 2019. PMID: 31197119 Free PMC article.
-
Emerging role of ubiquitination/deubiquitination modification of PD-1/PD-L1 in cancer immunotherapy.Genes Dis. 2022 Feb 18;10(3):848-863. doi: 10.1016/j.gendis.2022.01.002. eCollection 2023 May. Genes Dis. 2022. PMID: 37396527 Free PMC article. Review.
-
FBXW7 and human tumors: mechanisms of drug resistance and potential therapeutic strategies.Front Pharmacol. 2023 Nov 13;14:1278056. doi: 10.3389/fphar.2023.1278056. eCollection 2023. Front Pharmacol. 2023. PMID: 38027013 Free PMC article. Review.
-
The FBXW7-NOTCH interactome: A ubiquitin proteasomal system-induced crosstalk modulating oncogenic transformation in human tissues.Cancer Rep (Hoboken). 2021 Aug;4(4):e1369. doi: 10.1002/cnr2.1369. Epub 2021 Apr 6. Cancer Rep (Hoboken). 2021. PMID: 33822486 Free PMC article. Review.
-
Downregulation of specific FBXW7 isoforms with differential effects in T-cell lymphoblastic lymphoma.Oncogene. 2019 Jun;38(23):4620-4636. doi: 10.1038/s41388-019-0746-1. Epub 2019 Feb 11. Oncogene. 2019. PMID: 30742097
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
