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. 2015 Dec;30(6):1258-62.
doi: 10.1016/j.jcrc.2015.08.003. Epub 2015 Aug 5.

Predictors of intensive care unit length of stay and intracranial pressure in severe traumatic brain injury

Christos Lazaridis  1 , Ming Yang  2 , Stacia M DeSantis  2 , Sheng T Luo  2 , Claudia S Robertson  3
Affiliations

Predictors of intensive care unit length of stay and intracranial pressure in severe traumatic brain injury

Christos Lazaridis et al. J Crit Care. 2015 Dec.

Abstract

Objective: The aim of this study was to explore the relationship of intracranial pressure (ICP) with intensive care unit (ICU) length of stay in a large cohort of severe traumatic brain injury patients and identify factors associating with prolonged ICU course.

Methods: This was a single-center database review of de-identified research data that had been prospectively collected; setting: neurosurgical ICU, Ben Taub General Hospital, Houston, TX.

Results: In a cohort of 438 severe traumatic brain injury (TBI) patients, 149 (34%) had a motor Glasgow Coma Scale score of 1 to 3 on admission and 284 (65%) had 4 to 5. Intracranial pressure during the ICU course was 19.8±11.2 mm Hg. Favorable outcome was obtained in 148 (34%), and unfavorable, in 211 (48%) patients with a mortality of 28%. ICU length of stay (LOS) was 19.4±13.9 days. Joint modeling of ICP and ICU LOS was undertaken, adjusted for the International Mission for Prognosis and Analysis of Clinical Trials in TBI admission prognostic indicators. A higher ICP was not significantly associated with longer ICU LOS (P=.4). However, presence of a mass lesion on admission head computed tomography was strongly correlated with a prolonged ICU LOS (P=.0007). Diffuse injuries with basal cistern compression or midline shift were marginally associated with a longer ICU LOS (P=.053).

Conclusions: ICP, as monitored and managed according to BTF guidelines, is not associated with ICU length of stay. Patients with severe TBI and a mass lesion on admission head computed tomography were found to have prolonged ICU LOS independently of other indicators of injury severity and intracranial pressure course.

Keywords: Computed tomography; Intensive care unit; Intracranial pressure; Length of stay; Mass lesions; Traumatic brain injury.

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Conflict of interest statement

The authors report no conflicts of interest in relation to this manuscript. No funding has been received in relation to this manuscript. No reprints will be ordered.

Figures

Figure 1
Figure 1
CT classification categories and proportion of deaths vs. discharges from the ICU
See this image and copyright information in PMC

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