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Multicenter Study
. 2016;12(2):308-13.
doi: 10.1080/21645515.2015.1078952.

Serotype distribution of Streptococcus pneumoniae in children with invasive diseases in Turkey: 2008-2014

Mehmet Ceyhan  1 , Yasemin Ozsurekci  1 , Nezahat Gürler  2 , Lütfiye Öksüz  2 , Sohret Aydemir  3 , Sengul Ozkan  4 , Serife Yuksekkaya  5 , Melike Keser Emiroglu  6 , Meral Gültekin  7 , Akgün Yaman  8 , Abdurrahman Kiremitci  9 , Keramettin Yanık  10 , Arzu Karli  10 , Hatice Ozcinar  11 , Faruk Aydin  12 , Gulcin Bayramoglu  12 , Yasemin Zer  13 , Zeynep Gulay  14 , Efgan Dogan Gayyurhan  15 , Mustafa Gül  16 , Cüneyt Özakın  17 , Hüseyin Güdücüoğlu  18 , Duygu Perçin  19 , Nezahat Akpolat  20 , Candan Ozturk  21 , Yıldız Camcıoğlu  22 , Eda Karadağ Öncel  1 , Melda Çelik  1 , Laser Şanal  23 , Hakan Uslu  24
Affiliations
Multicenter Study

Serotype distribution of Streptococcus pneumoniae in children with invasive diseases in Turkey: 2008-2014

Mehmet Ceyhan et al. Hum Vaccin Immunother. 2016.

Abstract

Successful vaccination policies for protection from invasive pneumococcal diseases (IPD) dependent on determination of the exact serotype distribution in each country. We aimed to identify serotypes of pneumococcal strains causing IPD in children in Turkey and emphasize the change in the serotypes before and after vaccination with 7-valent pneumococcal conjugate vaccine (PCV-7) was included and PCV-13 was newly changed in Turkish National Immunization Program. Streptococcus pneumoniae strains were isolated at 22 different hospitals of Turkey, which provide healthcare services to approximately 65% of the Turkish population. Of the 335 diagnosed cases with S. pneumoniae over the whole period of 2008-2014, the most common vaccine serotypes were 19F (15.8%), 6B (5.9%), 14 (5.9%), and 3 (5.9%). During the first 5 y of age, which is the target population for vaccination, the potential serotype coverage ranged from 57.5 % to 36.8%, from 65.0% to 44.7%, and from 77.4% to 60.5% for PCV-7, PCV-10, and PCV-13 in 2008-2014, respectively. The ratio of non-vaccine serotypes was 27.2% in 2008-2010 whereas was 37.6% in 2011-2014 (p=0.045). S. penumoniae serotypes was less non-susceptible to penicillin as compared to our previous results (33.7 vs 16.5 %, p=0.001). The reduction of those serotype coverage in years may be attributed to increasing vaccinated children in Turkey and the increasing non-vaccine serotype may be explained by serotype replacement. Our ongoing IPD surveillance is a significant source of information for the decision-making processes on pneumococcal vaccination.

Keywords: S. pneumoniae; Turkey; epidemiology; serotypes; surveillance.

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Figures

Figure 1.
Figure 1.
Vaccine serotype coverage rates for PCV-7, PCV-10 and PCV-13 before and after inclusion of PCV-7 and PCV-13 in Turkey's NIP according to the years.
Figure 2.
Figure 2.
CONSORT flow diagram showing number of IPD cases enrolled in the study, study periods and vaccination status of the IPD cases according to the years.
See this image and copyright information in PMC

References

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