Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Dec;149(7):1731-1741.e3.
doi: 10.1053/j.gastro.2015.08.045. Epub 2015 Aug 29.

Burden of Gastrointestinal, Liver, and Pancreatic Diseases in the United States

Affiliations

Burden of Gastrointestinal, Liver, and Pancreatic Diseases in the United States

Anne F Peery et al. Gastroenterology. 2015 Dec.

Abstract

Background & aims: Gastrointestinal (GI), liver, and pancreatic diseases are a source of substantial morbidity, mortality, and cost in the United States. Quantification and statistical analyses of the burden of these diseases are important for researchers, clinicians, policy makers, and public health professionals. We gathered data from national databases to estimate the burden and cost of GI and liver disease in the United States.

Methods: We collected statistics on health care utilization in the ambulatory and inpatient setting along with data on cancers and mortality from 2007 through 2012. We included trends in utilization and charges. The most recent data were obtained from the Centers for Disease Control and Prevention, the Agency for Healthcare Research and Quality, and the National Cancer Institute.

Results: There were 7 million diagnoses of gastroesophageal reflux and almost 4 million diagnoses of hemorrhoids in the ambulatory setting in a year. Functional and motility disorders resulted in nearly 1 million emergency department visits in 2012; most of these visits were for constipation. GI hemorrhage was the most common diagnosis leading to hospitalization, with >500,000 discharges in 2012, at a cost of nearly $5 billion dollars. Hospitalizations and associated charges for inflammatory bowel disease, Clostridium difficile infection, and chronic liver disease have increased during the last 20 years. In 2011, there were >1 million people in the United States living with colorectal cancer. The leading GI cause of death was colorectal cancer, followed by pancreatic and hepatobiliary neoplasms.

Conclusions: GI, liver and pancreatic diseases are a source of substantial burden and cost in the United States.

Keywords: Abdominal Pain; GERD; Gastrointestinal Hemorrhage; IBS.

PubMed Disclaimer

Figures

FIGURE 1A
FIGURE 1A
Rising number of hospitalizations with associated or principal Clostridium difficile infection diagnoses
FIGURE 1B
FIGURE 1B
Rising charges for hospitalizations with principal Clostridium difficile infection diagnoses
FIGURE 1C
FIGURE 1C
Rising number of hospitalizations with principal diagnosis of inflammatory bowel disease, including Crohn’s disease or ulcerative colitis
FIGURE 1D
FIGURE 1D
Rising charges for hospitalizations for inflammatory bowel disease, including Crohn’s disease or ulcerative colitis
FIGURE 1E
FIGURE 1E
Rising number of hospitalizations with principal diagnosis of liver disease
FIGURE 1F
FIGURE 1F
Rising charges for hospitalizations for principal diagnosis of liver disease

Comment in

Similar articles

Cited by

References

    1. Peery AF, Dellon ES, Lund J, et al. Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology. 2012;143:1179–87. e1–3. - PMC - PubMed
    1. Research Portfolio Online Reporting Tools. National Institutes of Health; Feb 5, 2015. Estimates of Funding for Various Research C, and Disease Categories. Web. 19 Mar. 2015. < http://report.nih.gov/categorical_spending.aspx%3E.
    1. Sandler RS, Everhart JE, Donowitz M, et al. The burden of selected digestive diseases in the United States. Gastroenterology. 2002;122:1500–11. - PubMed
    1. Russo MW, Wei JT, Thiny MT, et al. Digestive and liver diseases statistics, 2004. Gastroenterology. 2004;126:1448–53. - PubMed
    1. Shaheen NJ, Hansen RA, Morgan DR, et al. The burden of gastrointestinal and liver diseases, 2006. Am J Gastroenterol. 2006;101:2128–38. - PubMed

Publication types

MeSH terms