Burden of Gastrointestinal, Liver, and Pancreatic Diseases in the United States
- PMID: 26327134
- PMCID: PMC4663148
- DOI: 10.1053/j.gastro.2015.08.045
Burden of Gastrointestinal, Liver, and Pancreatic Diseases in the United States
Abstract
Background & aims: Gastrointestinal (GI), liver, and pancreatic diseases are a source of substantial morbidity, mortality, and cost in the United States. Quantification and statistical analyses of the burden of these diseases are important for researchers, clinicians, policy makers, and public health professionals. We gathered data from national databases to estimate the burden and cost of GI and liver disease in the United States.
Methods: We collected statistics on health care utilization in the ambulatory and inpatient setting along with data on cancers and mortality from 2007 through 2012. We included trends in utilization and charges. The most recent data were obtained from the Centers for Disease Control and Prevention, the Agency for Healthcare Research and Quality, and the National Cancer Institute.
Results: There were 7 million diagnoses of gastroesophageal reflux and almost 4 million diagnoses of hemorrhoids in the ambulatory setting in a year. Functional and motility disorders resulted in nearly 1 million emergency department visits in 2012; most of these visits were for constipation. GI hemorrhage was the most common diagnosis leading to hospitalization, with >500,000 discharges in 2012, at a cost of nearly $5 billion dollars. Hospitalizations and associated charges for inflammatory bowel disease, Clostridium difficile infection, and chronic liver disease have increased during the last 20 years. In 2011, there were >1 million people in the United States living with colorectal cancer. The leading GI cause of death was colorectal cancer, followed by pancreatic and hepatobiliary neoplasms.
Conclusions: GI, liver and pancreatic diseases are a source of substantial burden and cost in the United States.
Keywords: Abdominal Pain; GERD; Gastrointestinal Hemorrhage; IBS.
Copyright © 2015 AGA Institute. Published by Elsevier Inc. All rights reserved.
Figures






Comment in
-
The Burden of Gastrointestinal, Liver, and Pancreatic Diseases: The Global Scenario.Gastroenterology. 2016 Apr;150(4):1045-6. doi: 10.1053/j.gastro.2016.01.036. Gastroenterology. 2016. PMID: 26930015 No abstract available.
Similar articles
-
Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2024.Gastroenterology. 2025 May;168(5):1000-1024. doi: 10.1053/j.gastro.2024.12.029. Epub 2025 Feb 4. Gastroenterology. 2025. PMID: 39920892
-
Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2018.Gastroenterology. 2019 Jan;156(1):254-272.e11. doi: 10.1053/j.gastro.2018.08.063. Epub 2018 Oct 10. Gastroenterology. 2019. PMID: 30315778 Free PMC article. Review.
-
Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2021.Gastroenterology. 2022 Feb;162(2):621-644. doi: 10.1053/j.gastro.2021.10.017. Epub 2021 Oct 19. Gastroenterology. 2022. PMID: 34678215 Free PMC article.
-
The Burden of Gastrointestinal, Liver, and Pancreatic Diseases: The Global Scenario.Gastroenterology. 2016 Apr;150(4):1045-6. doi: 10.1053/j.gastro.2016.01.036. Gastroenterology. 2016. PMID: 26930015 No abstract available.
-
Gastrointestinal and Hepatobiliary Disease in Cystic Fibrosis.Semin Respir Crit Care Med. 2019 Dec;40(6):825-841. doi: 10.1055/s-0039-1697591. Epub 2019 Oct 28. Semin Respir Crit Care Med. 2019. PMID: 31659728 Review.
Cited by
-
Enteric Glia Modulate Macrophage Phenotype and Visceral Sensitivity following Inflammation.Cell Rep. 2020 Sep 8;32(10):108100. doi: 10.1016/j.celrep.2020.108100. Cell Rep. 2020. PMID: 32905782 Free PMC article.
-
The Role of Series Cholecystectomy in High Risk Acute Cholecystitis Patients Who Underwent Gallbladder Drainage.Front Surg. 2021 Feb 15;8:630916. doi: 10.3389/fsurg.2021.630916. eCollection 2021. Front Surg. 2021. PMID: 33659271 Free PMC article.
-
Pain Control Disparities in Acute Pancreatitis.Cureus. 2022 Jul 31;14(7):e27507. doi: 10.7759/cureus.27507. eCollection 2022 Jul. Cureus. 2022. PMID: 36060399 Free PMC article.
-
Characteristics of Opioid Prescriptions to Veterans With Chronic Gastrointestinal Symptoms and Disorders Dually Enrolled in the Department of Veterans Affairs and Medicare Part D.Mil Med. 2021 Aug 28;186(9-10):943-950. doi: 10.1093/milmed/usab095. Mil Med. 2021. PMID: 33693755 Free PMC article.
-
Krüppel-like Factor 5 Plays an Important Role in the Pathogenesis of Chronic Pancreatitis.Cancers (Basel). 2023 Nov 15;15(22):5427. doi: 10.3390/cancers15225427. Cancers (Basel). 2023. PMID: 38001687 Free PMC article.
References
-
- Research Portfolio Online Reporting Tools. National Institutes of Health; Feb 5, 2015. Estimates of Funding for Various Research C, and Disease Categories. Web. 19 Mar. 2015. < http://report.nih.gov/categorical_spending.aspx%3E.
-
- Sandler RS, Everhart JE, Donowitz M, et al. The burden of selected digestive diseases in the United States. Gastroenterology. 2002;122:1500–11. - PubMed
-
- Russo MW, Wei JT, Thiny MT, et al. Digestive and liver diseases statistics, 2004. Gastroenterology. 2004;126:1448–53. - PubMed
-
- Shaheen NJ, Hansen RA, Morgan DR, et al. The burden of gastrointestinal and liver diseases, 2006. Am J Gastroenterol. 2006;101:2128–38. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical