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. 2015 Aug 28;21(32):9630-7.
doi: 10.3748/wjg.v21.i32.9630.

Efficacy of hepatic resection vs transarterial chemoembolization for solitary huge hepatocellular carcinoma

Shao-Liang Zhu  1 , Jian-Hong Zhong  1 , Yang Ke  1 , Liang Ma  1 , Xue-Mei You  1 , Le-Qun Li  1
Affiliations

Efficacy of hepatic resection vs transarterial chemoembolization for solitary huge hepatocellular carcinoma

Shao-Liang Zhu et al. World J Gastroenterol. .

Abstract

Aim: To compare the efficacy of hepatic resection (HR) and transarterial chemoembolization (TACE) for patients with solitary huge (≥ 10 cm) hepatocellular carcinoma (HCC).

Methods: Records were retrospectively analyzed of 247 patients with solitary huge HCC, comprising 180 treated by HR and 67 by TACE. Long-term overall survival (OS) was compared between the two groups using the Kaplan-Meier method, and independent predictors of survival were identified by multivariate analysis. These analyses were performed using all patients in both groups and/or 61 pairs of propensity score-matched patients from the two groups.

Results: OS at 5 years was significantly higher in the HR group than the TACE group, across all patients (P = 0.002) and across propensity score-matched pairs (36.4% vs 18.2%, P = 0.039). The two groups showed similar postoperative mortality and morbidity. Multivariate analysis identified alpha-fetoprotein ≥ 400 ng/mL, presence of vascular invasion and TACE treatment as independent predictors of poor OS.

Conclusion: Our findings suggest that HR can be safe and more effective than TACE for patients with solitary huge HCC.

Keywords: Hepatic resection; Overall survival; Propensity score matching; Solitary huge hepatocellular carcinoma; Transarterial chemoembolization.

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Figures

Figure 1
Figure 1
Flowchart of patient selection. HCC: Hepatocellular carcinoma; HR: Hepatic resection; TACE: Transarterial chemoembolization.
Figure 2
Figure 2
Comparison of overall survival across all study participants with solitary huge hepatocellular carcinoma undergoing hepatic resection or transarterial chemoembolization. HR: Hepatic resection; TACE: Transarterial chemoembolization.
Figure 3
Figure 3
Comparison of overall survival across propensity score-matched study participants with solitary huge hepatocellular carcinoma undergoing hepatic resection or transarterial chemoembolization. HR: Hepatic resection; TACE: Transarterial chemoembolization.
Figure 4
Figure 4
Disease-free survival in propensity score-matched patients with solitary huge hepatocellular carcinoma undergoing hepatic resection.
See this image and copyright information in PMC

References

    1. Venook AP, Papandreou C, Furuse J, de Guevara LL. The incidence and epidemiology of hepatocellular carcinoma: a global and regional perspective. Oncologist. 2010;15 Suppl 4:5–13. - PubMed
    1. Ferenci P, Fried M, Labrecque D, Bruix J, Sherman M, Omata M, Heathcote J, Piratsivuth T, Kew M, Otegbayo JA, et al. World Gastroenterology Organisation Guideline. Hepatocellular carcinoma (HCC): a global perspective. J Gastrointestin Liver Dis. 2010;19:311–317. - PubMed
    1. Zhong JH, Rodríguez AC, Ke Y, Wang YY, Wang L, Li LQ. Hepatic resection as a safe and effective treatment for hepatocellular carcinoma involving a single large tumor, multiple tumors, or macrovascular invasion. Medicine (Baltimore) 2015;94:e396. - PMC - PubMed
    1. Mok KT, Wang BW, Lo GH, Liang HL, Liu SI, Chou NH, Tsai CC, Chen IS, Yeh MH, Chen YC. Multimodality management of hepatocellular carcinoma larger than 10 cm. J Am Coll Surg. 2003;197:730–738. - PubMed
    1. Huang YH, Wu JC, Chen SC, Chen CH, Chiang JH, Huo TI, Lee PC, Chang FY, Lee SD. Survival benefit of transcatheter arterial chemoembolization in patients with hepatocellular carcinoma larger than 10 cm in diameter. Aliment Pharmacol Ther. 2006;23:129–135. - PubMed

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