Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Mar;14(1):35-40.
doi: 10.5114/pm.2015.49169. Epub 2015 Mar 25.

The APOB gene polymorphism in the pathogenesis of gallstone disease in pre- and postmenopausal women

Karolina Rudzińska  1 , Anna Bogacz  2 , Daniel Kotrych  3 , Hubert Wolski  4 , Marian Majchrzycki  5 , Agnieszka Seremak-Mrozikiewicz  6 , Bogusław Kosiński  7 , Bogusław Czerny  8
Affiliations

The APOB gene polymorphism in the pathogenesis of gallstone disease in pre- and postmenopausal women

Karolina Rudzińska et al. Prz Menopauzalny. 2015 Mar.

Abstract

Aim of the study: The decrease in estrogen levels in the postmenopausal period changes the lipid profile by the expression of hepatic genes related to metabolism of cholesterol and bile acid synthesis that could be important in the pathogenesis of cholelithiasis. The aim of the study was to determine the APOB gene 7673C>T and 12669G>A polymorphisms in the pathogenesis of gallstones and analysis of the composition of gallstones in pre- and postmenopausal women.

Material and methods: The study group consisted of 94 women qualified to the laparoscopic cholecystectomy while the control group consisted of 81 women in whom gallstones and other changes in the bile ducts were excluded. Gallstones composition analysis was performed using commercially available assays. The prevalence of the APOB gene polymorphisms was determined using the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP).

Results: When assessing the composition of gallstones in pre- and postmenopausal women, we observed differences in the studied parameters. Analysis of genetic variants of APOB gene 7673C>T and 12669G>A polymorphisms showed no significant statistical differences between studied groups and controls.

Conclusions: Analysis of 7673C>T and 12669G>A polymorphisms showed no relationship between specific genetic variants and the risk of gallstones in pre- and postmenopausal women, pointing to the fact that the investigated polymorphisms are not relevant as prognostic factors in gallstone disease in the Caucasian population. Because of the possible contribution of a variety of factors in gallstones pathogenesis the studies are required to take account of additional environmental factors, what may indicate different occurrence between investigated polymorphisms, gallstone disease development and gallstones composition in Caucasians.

Keywords: apolipoprotein B; gallstones; genetic polymorphism; menopause.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Hu FB, Grodstein F, Hennekens CH, et al. Age at natural menopause and risk of cardiovascular disease. Arch Intern Med. 1999;159:1061–1066. - PubMed
    1. Godziejewska-Zawada M. Otyłość i cukrzyca u kobiet w okresie menopauzy – zapobieganie i leczenie. Prz Menopauzalny. 2013;12:5–9.
    1. Portincasa P, Moschetta A, Palasciano G. Cholesterol gallstone disease. Lancet. 2006;368:230–240. - PubMed
    1. Mesalic L, Tupkovic E, Kendic S, et al. Correlation between hormonal and lipid status in women in menopause. Bosn J Basic Med Sci. 2008;8:188–192. - PMC - PubMed
    1. Silva MA, Wong T. Gallstones in chronic liver disease. J Gastrointest Surg. 2005;9:739–776. - PubMed