Preparation and Biosafety Assessment of Water-Soluble Hyperbranched Polyester Nanoparticles with Carboxylic Acid Functional Groups

Abstract

Biosafety assessment of nanoparticles has been of great interest in the development of nanoscience and nanotechnology. Here, the water-soluble hyperbranched polyester nanoparticles with carboxylic acid functional group (HBPE-CA NPs) are synthesized and characterized. They have amphiphilic structure that include hydrophobic hyperbranched polyester (HBPE) core and hydrophilic carboxylated terminal groups. Biosafety assessment tests of the HBPE-CA NPs include coagulation times, hemolysis, complement activation, platelet activation and cytotoxicity (MTT) are performed. The results show that the HBPE-CA NPs exhibit good hemocompatibility that strongly depend on the amphiphilic structure. Moreover, the results also indicate the non-cytotoxicity of the HBPE-CA NPs. So the HBPE-CA NPs provide a promising platform of blood circulation system for illness therapy with the help of the drug-loaded capacity of-HBPE.