Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Sep 1;5(9):a025148.
doi: 10.1101/cshperspect.a025148.

The Aging Heart

Ying Ann Chiao  1 , Peter S Rabinovitch  1
Affiliations
Review

The Aging Heart

Ying Ann Chiao et al. Cold Spring Harb Perspect Med. .

Abstract

Aging results in progressive deteriorations in the structure and function of the heart and is a dominant risk factor for cardiovascular diseases, the leading cause of death in Western populations. Although the phenotypes of cardiac aging have been well characterized, the molecular mechanisms of cardiac aging are just beginning to be revealed. With the continuously growing elderly population, there is a great need for interventions in cardiac aging. This article will provide an overview of the phenotypic changes of cardiac aging, the molecular mechanisms underlying these changes, and will present some of the recent advances in the development of interventions to delay or reverse cardiac aging.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
A schematic summary of the molecular mechanisms of cardiac aging and potential cardiac aging interventions. ROS, Reactive oxygen species; CR, calorie restriction; SS, Szeto–Schiller; miRNA, microRNA; ACE, angiotensin-converting enzyme; Ang, angiotensin.
See this image and copyright information in PMC

References

    1. Adlam VJ, Harrison JC, Porteous CM, James AM, Smith RA, Murphy MP, Sammut IA. 2005. Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury. FASEB J 19: 1088–1095. - PubMed
    1. Antonenko YN, Avetisyan AV, Bakeeva LE, Chernyak BV, Chertkov VA, Domnina LV, Ivanova OY, Izyumov DS, Khailova LS, Klishin SS, et al. 2008. Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1: Cationic plastoquinone derivatives: Synthesis and in vitro studies. Biochemistry (Mosc) 73: 1273–1287. - PubMed
    1. Anversa P, Rota M, Urbanek K, Hosoda T, Sonnenblick EH, Leri A, Kajstura J, Bolli R. 2005. Myocardial aging—A stem cell problem. Basic Res Cardiol 100: 482–493. - PubMed
    1. Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu PH, et al. 2005. Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle. Cell Metab 1: 259–271. - PubMed
    1. Bakeeva LE, Barskov IV, Egorov MV, Isaev NK, Kapelko VI, Kazachenko AV, Kirpatovsky VI, Kozlovsky SV, Lakomkin VL, Levina SB, et al. 2008. Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2: Treatment of some ROS- and age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke). Biochemistry (Mosc) 73: 1288–1299. - PubMed

Publication types

MeSH terms

LinkOut - more resources