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Review
. 2016 Jan;19(1):31-41.
doi: 10.1007/s10120-015-0537-5. Epub 2015 Sep 2.

Angiogenesis inhibitors in gastric and gastroesophageal junction cancer

Giandomenico Roviello  1 , Roberto Petrioli  2 , Luigi Marano  3 , Karol Polom  3 , Daniele Marrelli  4 , Armando Perrella  2 , Franco Roviello  3
Affiliations
Review

Angiogenesis inhibitors in gastric and gastroesophageal junction cancer

Giandomenico Roviello et al. Gastric Cancer. 2016 Jan.

Abstract

Despite significant improvements in systemic chemotherapy during the past two decades, the prognosis of patients with advanced gastric and gastroesophageal junction adenocarcinoma remains poor. Because of molecular heterogeneity, it is essential to classify tumors based on the underlying oncogenic pathways and to develop targeted therapies acting on individual tumors. Unfortunately, although a number of molecular targets have been studied, very few of these agents can be used in a clinical setting. In this review, we summarize the available data on anti-angiogenic agents in advanced/metastatic gastric cancer.

Keywords: Bevacizumab; Gastric cancer; Ramucirumab; VEGF.

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