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Comment
. 2015 Sep 2:13:71.
doi: 10.1186/s12915-015-0182-9.

In vivo studies of the Drosophila insulator factor CTCF reach a Catch 22

François Karch  1
Affiliations
Comment

In vivo studies of the Drosophila insulator factor CTCF reach a Catch 22

François Karch. BMC Biol. .

Abstract

Mutations in the proteins that bind insulator DNA elements that define the boundaries of chromatin domains can give morphogenetic readouts in Drosophila, as recently reported in BMC Biology by Bonchuk et al. in the Georgiev laboratory. But disentangling the effects on the phenotype may not be simple.See research article: http://www.biomedcentral.com/1741-7007/13/63.

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Figures

Fig. 1.
Fig. 1.
The Abd-B gene and its associated 3’ regulatory region (not drawn to scale) cover 165 kilobases of DNA. See text for explanation. Wild type (WT) (a) and Fab-7 1 (b) embryonic nerve cords stained with antibodies against Abd-B have been dissected out. Abdominal segments are numbered A5, A6, A7. Panel (a) shows the presence of CTCF binding sites at Mcp, Fab-6, Fab-8 and at the Abd-B promoter. The 5’-3’ polarity of the Abd-B transcription unit is indicated
See this image and copyright information in PMC

Comment on

References

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