Oxygen--a limiting factor for brain recovery
- PMID: 26329929
- PMCID: PMC4556415
- DOI: 10.1186/s13054-015-1034-2
Oxygen--a limiting factor for brain recovery
Abstract
Effective brain metabolism is highly dependent on a narrow therapeutic window of oxygen. In major insults to the brain (e.g., intracerebral hemorrhage), a slight decrease in oxygen supply, as occurs in a hypobaric environment at high altitude, has devastating effects on the injured brain tissue. Conversely, increasing brain oxygenation, by the use of hyperbaric oxygen therapy, can improve brain metabolism and its dependent regenerative processes.
Comment on
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Hyperbaric oxygen therapy ameliorates acute brain injury after porcine intracerebral hemorrhage at high altitude.Crit Care. 2015 Jun 15;19(1):255. doi: 10.1186/s13054-015-0976-8. Crit Care. 2015. PMID: 26073666 Free PMC article.
References
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- Zauner A, Daugherty WP, Bullock MR, Warner DS. Brain oxygenation and energy metabolism: part I-biological function and pathophysiology. Neurosurgery. 2002;51:289–301. - PubMed
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