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Review
. 2015 Aug;15(4):191-8.
doi: 10.4110/in.2015.15.4.191. Epub 2015 Aug 26.

Immune-mediated Liver Injury in Hepatitis B Virus Infection

In Soo Oh  1 , Su-Hyung Park  2
Affiliations
Review

Immune-mediated Liver Injury in Hepatitis B Virus Infection

In Soo Oh et al. Immune Netw. 2015 Aug.

Abstract

Hepatitis B virus (HBV) is responsible for approximately 350 million chronic infections worldwide and is a leading cause of broad-spectrum liver diseases such as hepatitis, cirrhosis and liver cancer. Although it has been well established that adaptive immunity plays a critical role in viral clearance, the pathogenetic mechanisms that cause liver damage during acute and chronic HBV infection remain largely known. This review describes our current knowledge of the immune-mediated pathogenesis of HBV infection and the role of immune cells in the liver injury during hepatitis B.

Keywords: Hepatitis B Virus; Immune response; Pathogenesis.

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Conflict of interest statement

CONFLICTS OF INTEREST: The authors have no financial conflict of interest.

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