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. 2015 Jul;10(7):1050-2.
doi: 10.4103/1673-5374.160076.

Streptozotocin induced Alzheimer's disease like changes and the underlying neural degeneration and regeneration mechanism

Pradip Kumar Kamat  1
Affiliations

Streptozotocin induced Alzheimer's disease like changes and the underlying neural degeneration and regeneration mechanism

Pradip Kumar Kamat. Neural Regen Res. 2015 Jul.
No abstract available

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Figures

Figure 1
Figure 1
The flow diagram represents the streptozotocin (STZ) mediated free radical generation and their influence on oxidative stress, apoptotic cell death and neuroinflammation. These entire pathological factors collectively affect the neuronal function which may further implicate in Alzheimer's disease pathology.
Figure 2
Figure 2
The cartoon illustrates the role of streptozotocin (STZ) in damage of pancreatic beta cells which lead to insulin deficiency. On the other hand, STZ also enhances low insulin level and impaired insulin receptor in brain that causes alteration of glycogen synthase kinase. Therefore, these alterations stimulate increased tau phosphorylation, formation of neurofibrillary tangle and finally implicated in neuronal and synapse dysfunction resulting into Alzheimer's disease like pathology. GLUT-2: Glucose transporter 2; GSK3β: glycogen synthase kinase β; Aβ: amyloid beta.
See this image and copyright information in PMC

References

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