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Comment
. 2015 Sep 1;22(3):365-6.
doi: 10.1016/j.cmet.2015.08.004.

Members Only: Hypoxia-Induced Cell-Cycle Activation in Cardiomyocytes

Arun Sharma  1 , Sean M Wu  2
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Members Only: Hypoxia-Induced Cell-Cycle Activation in Cardiomyocytes

Arun Sharma et al. Cell Metab. .
Free article

Abstract

A low level of cardiomyocyte turnover occurs in the adult mammalian heart, but the source of these new cells remains unknown. Kimura et al., 2015 utilized a novel hypoxia-induced fate mapping system to identify a rare population of adult cardiomyocytes undergoing cell-cycle entry and expansion in healthy adult hearts and following ischemic injury.

Keywords: Cardiomyocyte; hypoxia; proliferation.

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  • Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart.
    Kimura W, Xiao F, Canseco DC, Muralidhar S, Thet S, Zhang HM, Abderrahman Y, Chen R, Garcia JA, Shelton JM, Richardson JA, Ashour AM, Asaithamby A, Liang H, Xing C, Lu Z, Zhang CC, Sadek HA. Kimura W, et al. Nature. 2015 Jul 9;523(7559):226-30. doi: 10.1038/nature14582. Epub 2015 Jun 22. Nature. 2015. PMID: 26098368

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