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Case Reports
. 2015 Sep;51(9):927-31.
doi: 10.1111/jpc.12823.

Losartan therapy for cardiac disease in paediatricMarfan syndrome

Lisa J Ewans  1 , Phillip Roberts  2 , Lesley Adès  1
Affiliations
Case Reports

Losartan therapy for cardiac disease in paediatricMarfan syndrome

Lisa J Ewans et al. J Paediatr Child Health. 2015 Sep.

Abstract

A case of severe early-onset Marfan syndrome (MFS) led us to ask the question: 'Should an ARB, particularly losartan [intervention], compared with beta blockade alone [comparison], be commenced in all paediatric MFS patients [patient] with aortic root dilatation [outcome]?' The current literature was critically appraised to address this question.

Keywords: cardiology; genetics; pharmacology.

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