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Comparative Study
. 2015 Nov;17(11):988-93.
doi: 10.1111/hpb.12479. Epub 2015 Sep 3.

Outcomes of resection of giant hepatocellular carcinoma in a tertiary institution: does size matter?

Yongxian Thng  1 , Jarrod K H Tan  2 , Iyer G Shridhar  1 , Stephen K Y Chang  1 , Krishnakumar Madhavan  1 , Alfred W C Kow  1
Affiliations
Comparative Study

Outcomes of resection of giant hepatocellular carcinoma in a tertiary institution: does size matter?

Yongxian Thng et al. HPB (Oxford). 2015 Nov.

Abstract

Background: The surgical management of giant hepatocellular carcinoma (G-HCC), or HCC of ≥10 cm in diameter, remains controversial. The aim of this study was to compare the outcomes of surgical resection of, respectively, G-HCC and small HCC (S-HCC), or HCC measuring <10 cm.

Methods: A retrospective review of all patients (n = 86) diagnosed with HCC and submitted to resection in a tertiary hospital during the period from January 2007 to June 2012 was conducted. Overall survival (OS), recurrence rates and perioperative mortality at 30 days were compared between patients with, respectively, G-HCC and S-HCC. Prognostic factors for OS were analysed.

Results: The sample included 23 patients with G-HCC (26.7%) and 63 with S-HCC (73.3%) based on histological tumour size. Patient demographics and comorbidities were comparable. Median OS was 39.0 months in patients with G-HCC and 65.0 months in patients with S-HCC (P = 0.213). Although size did not affect OS in this cohort, the presence of satellite lesions [hazard ratio (HR) 3.70, P = 0.012] and perioperative blood transfusion (HR 2.85, P = 0.015) were negative predictors for OS.

Conclusions: Surgical resection of G-HCC provides OS comparable with that after resection of S-HCC.

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Figures

Figure 1
Figure 1
Overall survival in patients submitted to resection of hepatocellular carcinoma (HCC), showing comparisons between subgroups of patients with giant HCC (G-HCC) and small HCC (S-HCC), respectively
See this image and copyright information in PMC

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