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. 2015 Nov 15;61(10):1601-3.
doi: 10.1093/cid/civ778. Epub 2015 Sep 1.

No New HIV Infections With Increasing Use of HIV Preexposure Prophylaxis in a Clinical Practice Setting

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No New HIV Infections With Increasing Use of HIV Preexposure Prophylaxis in a Clinical Practice Setting

Jonathan E Volk et al. Clin Infect Dis. .

Abstract

Referrals for and initiation of preexposure prophylaxis (PrEP) for human immunodeficiency virus (HIV) infection increased dramatically in a large clinical practice setting since 2012. Despite high rates of sexually transmitted infections among PrEP users and reported decreases in condom use in a subset, there were no new HIV infections in this population.

Keywords: HIV; behavioral disinhibition; men who have sex with men; preexposure prophylaxis; sexually transmitted infections.

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Figures

Figure 1.
Figure 1.
Human immunodeficiency virus preexposure prophylaxis (PrEP) referrals, intakes, and initiation by month at Kaiser Permanente San Francisco, July 2012–February 2015. The graph includes a total of 1045 referrals, 835 intakes, and 677 initiations, including 20 individuals who restarted PrEP after discontinuing during the study period.

Comment in

References

    1. Grant RM, Lama JR, Anderson PL et al. . Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med 2010; 363:2587–99. - PMC - PubMed
    1. Grant RM, Anderson PL, McMahan V et al. . Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort study. Lancet Infect Dis 2014; 14:820–9. - PMC - PubMed
    1. Cohen SE, Vittinghoff E, Bacon O et al. . High interest in preexposure prophylaxis among men who have sex with men at risk for HIV infection: baseline data from the US PrEP Demonstration Project. J Acquir Immune Defic Syndr 2015; 68:439–48. - PMC - PubMed
    1. Wilton J, Senn H, Sharma M, Tan DH. Pre-exposure prophylaxis for sexually-acquired HIV risk management: a review. HIV AIDS (Auckl) 2015; 7:125–36. - PMC - PubMed
    1. Marcus JL, Glidden DV, Mayer KH et al. . No evidence of sexual risk compensation in the iPrEx trial of daily oral HIV preexposure prophylaxis. PLoS One 2013; 8:e81997. - PMC - PubMed

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