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. 2016 Jan 1;71(1):65-9.
doi: 10.1097/QAI.0000000000000812.

Brief Report: Effects of Tenofovir and Amphotericin B Deoxycholate Coadministration on Kidney Function in Patients Treated for Cryptococcal Meningitis

Reuben Kiggundu  1 , Bozena M Morawski, Nathan C Bahr, Joshua Rhein, Abdu K Musubire, Darlisha A Williams, Mahsa Abassi, Henry W Nabeta, Kathy H Hullsiek, David B Meya, David R Boulware; ASTRO-CM Team
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Brief Report: Effects of Tenofovir and Amphotericin B Deoxycholate Coadministration on Kidney Function in Patients Treated for Cryptococcal Meningitis

Reuben Kiggundu et al. J Acquir Immune Defic Syndr. .

Abstract

The effect of tenofovir and amphotericin coadministration on kidney function is poorly characterized. We measured creatinine during induction therapy and at 4 weeks after diagnosis in Ugandans undergoing cryptococcal meningitis therapy and classified as not receiving antiretroviral therapy (ART), receiving nontenofovir ART or receiving tenofovir-based ART. Longitudinal creatinine changes and grade 2-4 creatinine adverse events were evaluated across groups. Creatinine concentrations were similar across ART groups. At 4 weeks after diagnosis, creatinine was 0.25 mg/dL higher than at diagnosis, but similar across groups. Adverse event incidence was also similar across ART groups. Tenofovir and amphotericin coadministration did not increase the risk of kidney dysfunction.

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Conflict of interest statement

Conflicts: There are no conflicts of interest.

Figures

Figure 1
Figure 1
Median (IQR) serum creatinine in persons receiving no ART (white), ART without tenofovir (light gray) and ART with tenofovir (dark gray) at meningitis diagnosis, from diagnosis through 4 weeks follow-up.
See this image and copyright information in PMC

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