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Review
. 2015 Oct;58(10):976-84.
doi: 10.1007/s11427-015-4891-7.

Autism spectrum disorder model mice: Focus on copy number variation and epigenetics

Nobuhiro Nakai  1   2   3 , Susumu Otsuka  1 , Jihwan Myung  1   3 , Toru Takumi  4   5   6
Affiliations
Review

Autism spectrum disorder model mice: Focus on copy number variation and epigenetics

Nobuhiro Nakai et al. Sci China Life Sci. 2015 Oct.

Abstract

Autism spectrum disorder (ASD) is gathering concerns in socially developed countries. ASD is a neuropsychiatric disorder of genetic origin with high prevalence of 1%-2%. The patients with ASD characteristically show impaired social skills. Today, many genetic studies identify numerous susceptible genes and genetic loci associated with ASD. Although some genetic factors can lead to abnormal brain function linked to ASD phenotypes, the pathogenic mechanism of ASD is still unclear. Here, we discuss a new mouse model for ASD as an advanced tool to understand the mechanism of ASD.

Keywords: ASD model mouse; DNA methylation; copy number variations; histone modification.

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