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. 2015:463:239-42.
doi: 10.1134/S1607672915040110. Epub 2015 Sep 3.

Structural and functional analyses of the sixth site of neurexin alternative splicing

O V Serova  1 , N V Radionov, D M Shayahmetova, I E Deyev, A G Petrenko
Affiliations

Structural and functional analyses of the sixth site of neurexin alternative splicing

O V Serova et al. Dokl Biochem Biophys. 2015.

Abstract

In this study, we found the sixth site of alternative splicing (SS6) of neurexin 1a from the rat brain. This site is located between the fifth LNS and the third EGF-like domains. The insertion in the SS6 site corresponds to the 9-residue peptide VALMKADLQ, which is conserved among animals. We demonstrated that the SS6 insertion regulates tissue-specific expression of neurexin 1α.

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