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. 2014 Mar;11(1):26-9.
doi: 10.5114/kitp.2014.41926. Epub 2014 Mar 27.

The effect of preoperative albendazole treatment on the cuticular membranes of pulmonary hydatid cysts: should it be administered preoperatively?

Ozan Usluer  1 , Seyda Ors Kaya  1 , Ozgur Samancilar  1 , Kenan Can Ceylan  1 , Soner Gursoy  1
Affiliations

The effect of preoperative albendazole treatment on the cuticular membranes of pulmonary hydatid cysts: should it be administered preoperatively?

Ozan Usluer et al. Kardiochir Torakochirurgia Pol. 2014 Mar.

Abstract
in English, Polish

The aim of this study: The aim of this study was to investigate the effects of preoperative albendazole treatment on the tensile strength of the cuticular membranes of pulmonary hydatid cysts.

Material and methods: A study including 44 patients operated on for pulmonary hydatid cysts was carried out between January 2009 and November 2010. The patients were divided into two groups according to their preoperative albendazole administration. Seventeen patients (with 20 cysts) in group A were operated on after three cycles of peroral 10 mg/kg/day albendazole treatment, whereas 27 patients (with 29 cysts) in group B underwent the operation without any preoperative administration of albendazole. Fresh tissue tensile stress tests were carried out on the cuticular membranes excised from both groups.

Results: The results of this study demonstrated that the tensile strength values of the cuticular membrane of the cysts excised from group A were lower than those obtained from group B, with a statistically significant difference.

Conclusions: Albendazole treatment decreases the tensile strength of the cuticular membranes of pulmonary hydatid cysts, which may lead to their perforation. The patients should be operated on as soon as possible and without any preoperative medical treatment in order to prevent complications before the definitive surgical operation.

Celem pracy: Celem pracy było zbadanie wpływu przedoperacyjnego leczenia albendazolem na błonę oskórkową torbieli bąblowca w płucach.

Materiał i metody: Badaniem objęto 44 osoby operowane z powodu obecności torbieli bąblowca w płucach pomiędzy styczniem 2009 a listopadem 2010 r. Pacjenci zostali podzieleni na dwie grupy zgodnie z przedoperacyjnym podawaniem albendazolu. Siedemnastu pacjentów (z 20 torbielami) w grupie A otrzymywało przed operacją 3 doustne cykle albendazolu w dawce 10 mg/kg m.c./dobę, podczas gdy 27 pacjentów (z 29 torbielami) w grupie B nie otrzymywało przed operacją albendazolu. Testy wytrzymałości na rozciąganie przeprowadzano na świeżych tkankach błon oskórkowych usuwanych z płuc pacjentów obu grup.

Wyniki: Wykazano, że wartości wytrzymałości na rozciąganie błon oskórkowych torbieli wycinanych w grupie A były niższe niż uzyskane w grupie B, a różnica pomiędzy nimi była istotna statystycznie.

Wnioski: Leczenie albendazolem zmniejsza wytrzymałość na rozciąganie błon oskórkowych płucnych torbieli bąblowca, co może prowadzić do ich perforacji. Chorzy powinni być operowani w najszybszym możliwym terminie, bez dodatkowej terapii przedoperacyjnej, aby uniknąć powikłań przed definitywnym leczeniem chirurgicznym.

Keywords: albendazole; hydatid disease; in vitro studies; lung; surgery.

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Figures

Fig. 1
Fig. 1
Photograph of the tensiometer that was used in the study
Fig. 2
Fig. 2
Chest X-ray of a giant cyst in the non-albendazole group
Fig. 3
Fig. 3
Computed tomography scan of the patient presented in Figure 2
See this image and copyright information in PMC

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