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. 2015 Nov;64(11):841-4.
doi: 10.1007/s00011-015-0871-4. Epub 2015 Sep 4.

Nurr1 reduction influences the onset of chronic EAE in mice

Francesca Montarolo  1 , Simona Perga  2 , Serena Martire  2 , Antonio Bertolotto  2
Affiliations

Nurr1 reduction influences the onset of chronic EAE in mice

Francesca Montarolo et al. Inflamm Res. 2015 Nov.

Abstract

Objective: Nurr1 plays anti-inflammatory functions in astrocytes/microglia. Gene expression analysis reveals Nurr1 down-regulation in PBMCs of MS patients that negatively correlates with disease aggressiveness. This study assesses the consequences of Nurr1 reduction in a MS model represented by EAE.

Methods: EAE was induced in heterozygous Nurr1 knockout mice. Clinical course was evaluated during pre-symptomatic, acute, and chronic phases. Neurohistopathological state was analyzed in spinal cord.

Results and conclusions: Nurr1 defect induces early EAE onset and increases inflammatory infiltrates in spinal cord suggesting a Nurr1 role in the early phase of EAE.

Keywords: Experimental autoimmune encephalomyelitis; Inflammation; Multiple sclerosis; Nurr1.

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