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Multicenter Study
. 2015 Oct 6;6(30):28743-54.
doi: 10.18632/oncotarget.4926.

Genetic interaction of P2X7 receptor and VEGFR-2 polymorphisms identifies a favorable prognostic profile in prostate cancer patients

Anna Solini  1 , Vittorio Simeon  2 , Lisa Derosa  3 , Paola Orlandi  1 , Chiara Rossi  1 , Andrea Fontana  3 , Luca Galli  3 , Teresa Di Desidero  1 , Anna Fioravanti  1 , Sara Lucchesi  4 , Luigi Coltelli  4 , Laura Ginocchi  4 , Giacomo Allegrini  4 , Romano Danesi  1 , Alfredo Falcone  3 , Guido Bocci  1
Affiliations
Multicenter Study

Genetic interaction of P2X7 receptor and VEGFR-2 polymorphisms identifies a favorable prognostic profile in prostate cancer patients

Anna Solini et al. Oncotarget. .

Abstract

VEGFR-2 and P2X7 receptor (P2X7R) have been described to stimulate the angiogenesis and inflammatory processes of prostate cancer. The present study has been performed to investigate the genetic interactions among VEGFR-2 and P2X7R SNPs and their correlation with overall survival (OS) in a population of metastatic prostate cancer patients. Analyses were performed on germline DNA obtained from blood samples and SNPs were investigated by real-time PCR technique. The survival dimensionality reduction (SDR) methodology was applied to investigate the genetic interaction between SNPs. One hundred patients were enrolled. The SDR software provided two genetic interaction profiles consisting of the combination between specific VEGFR-2 (rs2071559, rs11133360) and P2X7R (rs3751143, rs208294) genotypes. The median OS was 126 months (95% CI, 115.94-152.96) and 65.65 months (95% CI, 52.95-76.53) for the favorable and the unfavorable genetic profile, respectively (p < 0.0001). The genetic statistical interaction between VEGFR-2 (rs2071559, rs11133360) and P2X7R (rs3751143, rs208294) genotypes may identify a population of prostate cancer patients with a better prognosis.

Keywords: P2X7 receptor; VEGFR-2; polymorphisms; prostate cancer; survival dimensionality reduction analysis.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1. Overall survival curve of all patients (A), and overall survival curves according to the favorable and unfavorable genetic profiles (B). Survival curves were calculated by the Kaplan Meier method
CI, confidence interval.
See this image and copyright information in PMC

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