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Review
. 2015 Sep 3;5(9):e008541.
doi: 10.1136/bmjopen-2015-008541.

Association between adiponectin levels and endometrial carcinoma risk: evidence from a dose-response meta-analysis

Tong Lin  1 , Xin Zhao  1 , Wei-min Kong  2
Affiliations
Review

Association between adiponectin levels and endometrial carcinoma risk: evidence from a dose-response meta-analysis

Tong Lin et al. BMJ Open. .

Erratum in

  • Correction.
    [No authors listed] [No authors listed] BMJ Open. 2016 Mar 22;6(3):e008541corr1. doi: 10.1136/bmjopen-2015-008541corr1. BMJ Open. 2016. PMID: 27006340 Free PMC article. No abstract available.

Abstract

Objectives: Epidemiological studies evaluating the association between adiponectin levels and endometrial carcinoma risk have produced inconsistent results. Thus, a meta-analysis was conducted to assess the association between them.

Methods: Pertinent studies were identified by a search of PubMed and Web of Knowledge through January of 2015. A random-effects model was used to combine the data for analysis. Dose-response relationship was assessed by restricted cubic spline and variance-weighted least squares regression analysis.

Results: Twelve articles (5 prospective studies and 7 case-control studies) involving 1916 endometrial carcinoma cases were included in this meta-analysis. Pooled results suggested that highest adiponectin levels versus lowest levels were significantly associated with the risk of endometrial carcinoma (summary relative risk (RR)=0.525, 95% CI 0.388 to 0.712, I(2)=64.2%). The association was also found in postmenopausal women (summary RR=0.646, 95% CI 0.433 to 0.964), but not in premenopausal women. A linear dose-response relationship was found, with the risk of endometrial carcinoma decreasing by 3% for every 1 μg/mL increase in adiponectin levels (summary RR=0.97, 95% CI 0.96 to 0.98). No publication bias was found.

Conclusions: Our analysis suggested that the higher adiponectin levels might have a protective effect against endometrial carcinoma, especially in postmenopausal women.

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Figures

Figure 1
Figure 1
The flow diagram of screened, excluded and analysed publications. RR, relative risk.
Figure 2
Figure 2
The forest plot between highest versus lowest categories of adiponectin levels and endometrial carcinoma risk.
Figure 3
Figure 3
Dose–response meta-analyses of every 1 μg/mL increase in adiponectin levels and the risk of endometrial carcinoma. Squares represent study-specific RR, horizontal lines represent 95% CI and diamonds represent summary relative risks. RR, relative risk.
Figure 4
Figure 4
Begg's funnel plot for publication bias of adiponectin levels and endometrial carcinoma risk.
See this image and copyright information in PMC

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