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Review
. 2015 Jul 1;8(7):8516-20.
eCollection 2015.

Littoral cell angioma of the spleen: report of three cases and literature review

Jun Du  1 , Qin Shen  2 , Honglin Yin  2 , Xiaojun Zhou  2 , Bo Wu  2
Affiliations
Review

Littoral cell angioma of the spleen: report of three cases and literature review

Jun Du et al. Int J Clin Exp Pathol. .

Abstract

Littoral cell angioma (LCA) is an extremely rare benign splenic tumor with typical histomorphologic features, which is difficult to be distinguished preoperatively from other benign or malignant splenic tumors. It is a unique vascular tumor of the spleen, with abdominal pain or as an incidental finding when undergoing physical examination. In this paper, we reported three cases of LCA treated in our hospital. Their clinical symptoms, pathological features, clinical treatment as well as the prognosis are discussed.

Keywords: LCA; Littoral cell angioma; splenic tumor; vascular neoplasm.

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Figures

Figure 1
Figure 1
MRI show diffuse hypo-dense splenic masses.
Figure 2
Figure 2
Multiple hemorrhagic focus and capsular space in the incisional surface.
Figure 3
Figure 3
Large sinus-like anastomosing channels, with deciduous endothelial cells in the channel.
Figure 4
Figure 4
Anastomosing channels lined by tall and plump cells, showing micropapillary architecture in some regions, but without nuclear atypia or mitotic activity. Deposition of hemosiderin can be seen in some cells.
Figure 5
Figure 5
The anastomosing channels lined cells express antigen CD31.
Figure 6
Figure 6
Endothelium of peripheral vessels express antigen CD34, but not the anastomosing channels lined cells.
Figure 7
Figure 7
CD68 were positively expressed.
Figure 8
Figure 8
The anastomosing channels lined cells express antigen FVIII.
Figure 9
Figure 9
Some lined cells of channels were positive for PAS stain.
Figure 10
Figure 10
Electron microscopy, no smooth muscle can be found outside the vessel wall, but a layer of homogeneous, which is a kind of basilar membrane-like materials with medium electronics density.
Figure 11
Figure 11
The cytoplasm is rich of mitochondria, rough endoplasmic, and partly with plenty of glycogen.
Figure 12
Figure 12
Bundles of intermediate filament distribute in some cells.
See this image and copyright information in PMC

References

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