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Editorial
. 2015 Oct;26(5):470-1.
doi: 10.1097/MOL.0000000000000220.

Regulatory B cells, interleukin-10, and atherosclerosis

Hong Lu  1 , Alan Daugherty
Affiliations
Editorial

Regulatory B cells, interleukin-10, and atherosclerosis

Hong Lu et al. Curr Opin Lipidol. 2015 Oct.
No abstract available

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Conflict of interest statement

Conflicts of interest

There are no conflicts of interest.

Comment on

References

REFERENCES AND RECOMMENDED READING

    1. Strom AC, Cross AJ, Cole JE, et al. B regulatory cells are increased in hypercholesterolemic mice and protect from lesion development via IL-10. Thromb Haemost. 2015 Jun 11;114 [Epub ahead of print] This article provides insights into understanding regulatory B cell/interleukin-10-mediated mechanisms of atherosclerosis in a carotid arterial injury mouse model.

    1. Sage AP, Nus M, Baker LL, et al. Regulatory B cell-specific interleukin-10 is dispensable for atherosclerosis development in mice. Arterioscler Thromb Vasc Biol. 2015 Jun 18;35 [Epub ahead of print] This brief report determined effects of interleukin-10 in regulatory B cells on the development of atherosclerosis in low-density lipoprotein receptor knockout mice.

    1. Fillatreau S, Sweenie CH, McGeachy MJ, et al. B cells regulate autoimmunity by provision of IL-10. Nat Immunol. 2002;3:944–950. - PubMed
    1. Mauri C, Gray D, Mushtaq N, et al. Prevention of arthritis by interleukin 10-producing B cells. J Exp Med. 2003;197:489–501. - PMC - PubMed
    1. Rosser EC, Oleinika K, Tonon S, et al. Regulatory B cells are induced by gut microbiota-driven interleukin-1beta and interleukin-6 production. Nat Med. 2014;20:1334–1339. - PubMed

FURTHER RECOMMENDED READING

    1. Wolf D, Zirlik A, Ley K. Beyond vascular inflammation-recent advances in understanding atherosclerosis. Cell Mol Life Sci. 2015 Jun 23; [Epub ahead of print] This article reviews studies that have provided landmark influences on understanding the pathophysiological development and molecular mechanisms of atherosclerosis.

    1. Ammirati E, Moroni F, Magnoni M, et al. The role of T and B cells in human atherosclerosis and atherothrombosis. Clin Exp Immunol. 2015;179:173–187. This article reviews studies that have determined roles of adaptive immunity on the development of atherosclerosis and thrombosis, which provide insights into understanding immunity-related mechanisms of atherosclerotic diseases.

    1. Clement M, Guedj K, Andreata F, et al. Control of the T follicular helper-germinal center B-cell axis by CD8+ regulatory T cells limits atherosclerosis and tertiary lymphoid organ development. Circulation. 2015;131:560–570. The authors report that T follicular helper-germinal center B-cell axis contributes to the development of atherosclerosis in a hypercholesterolemic mouse model.

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