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. 2015 Sep 4;10(9):e0137313.
doi: 10.1371/journal.pone.0137313. eCollection 2015.

Antimicrobial Susceptibility of Invasive Streptococcus pyogenes Isolates in Germany during 2003-2013

Matthias Imöhl  1 , Mark van der Linden  1
Affiliations

Antimicrobial Susceptibility of Invasive Streptococcus pyogenes Isolates in Germany during 2003-2013

Matthias Imöhl et al. PLoS One. .

Abstract

A nationwide laboratory-based surveillance study of invasive S. pyogenes infections was conducted in Germany. Invasive isolates (n = 1,281) were obtained between 2003 and 2013. All isolates were susceptible to penicillin, cefotaxime and vancomycin. Tetracycline showed the highest rate of resistant or intermediate resistant isolates with 9.8%, followed by macrolides (4.0%), trimethoprim/sulfamethoxazole (SXT) (1.9%), levofloxacin (1.3%), chloramphenicol (0.9%) and clindamycin (0.7%). The most prominent trends were the appearance of levofloxacin non-susceptible isolates since 2011, and an increase of SXT non-susceptibility since 2012.

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Conflict of interest statement

Competing Interests: ML has been a member of advisory boards for and has received research grants and speakers’ honorary fees from Pfizer, GSK, Merck and SanofiPasteurMSD. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

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