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Meta-Analysis
. 2015 Sep;32(9):1421-7.
doi: 10.1007/s10815-015-0566-3. Epub 2015 Sep 4.

Association between IL-6 -174 G/C, IL-6 -634 G/C, and IFN-γ +874 A/T polymorphisms and susceptibility to recurrent pregnancy loss: a meta-analysis

Young Ho Lee  1 , Sung Jae Choi  2 , Jong Dae Ji  2
Affiliations
Meta-Analysis

Association between IL-6 -174 G/C, IL-6 -634 G/C, and IFN-γ +874 A/T polymorphisms and susceptibility to recurrent pregnancy loss: a meta-analysis

Young Ho Lee et al. J Assist Reprod Genet. 2015 Sep.

Abstract

Objective: The aim of this study was to determine whether interleukin-6 (IL-6) -174 G/C, IL-6 -634 G/C, and interferon-γ (IFN-γ) +874 A/T polymorphisms are associated with susceptibility to recurrent pregnancy loss (RPL).

Methods: We conducted a literature search using PubMed and EMBASE databases and performed a meta-analysis using fixed- or random-effects models.

Results: A total of 15 articles met the study inclusion criteria. When all study subjects were considered together, meta-analysis showed no association between RPL and the IL-6 -174 GG + GC genotype (odds ratio [OR] = 0.794, 95 % confidence interval [CI] = 0.542-1.163, p = 0.236). However, stratification of the data by ethnicity indicated an association between this genotype and RPL in non-Caucasians (OR = 0.528, 95 % CI = 0.302-0.925, p = 0.028), but not in Caucasian populations. Moreover, meta-analysis revealed an association between RPL and the IL-6 -634 GG + GC genotype in all study subjects (OR = 0.556, 95 % CI = 0.383-0.806, p = 0.002), while stratification by ethnicity revealed a negative association between this genotype and RPL in Asian (OR = 0.545, 95 % CI = 0.371-0.800, p = 0.002) but not Middle Eastern populations. Furthermore, a relationship between the IFN-γ +874 A allele and RPL was identified in non-Caucasians (OR = 1.403, 95 % CI = 1.133-1.734, p = 0.002), but not in Caucasians.

Conclusions: This meta-analysis demonstrates that IL-6 -174 G/C, IL-6 -634 G/C, and IFN-γ +874 A/T polymorphisms are associated with susceptibility to RPL, particularly in non-Caucasians.

Keywords: IFN-γ; IL-6; Meta-analysis; Polymorphism; RPL.

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Figures

Fig. 1
Fig. 1
Odds ratios (ORs) and 95 % confidence intervals (CIs) from individual studies and pooled data for the association between the GG + GC genotype of the IL-6 −174 G/C (a) and −634 G/C (b) polymorphisms and RPL in Caucasian and non-Caucasian populations
Fig. 2
Fig. 2
Odds ratios (ORs) and 95 % confidence intervals (CIs) from individual studies and pooled data for the association between the GG + GC genotype of the IFN-γ +874 A/T polymorphism and RPL in Asian and Middle Eastern populations
See this image and copyright information in PMC

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