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Review
. 2015 Sep-Oct;19(5):510-6.
doi: 10.1016/j.bjid.2015.06.011. Epub 2015 Sep 3.

The role of microRNAs in enteroviral infections

Jing Wu  1 , Li Shen  2 , Jianguo Chen  3 , Huaxi Xu  1 , Lingxiang Mao  4
Affiliations
Review

The role of microRNAs in enteroviral infections

Jing Wu et al. Braz J Infect Dis. 2015 Sep-Oct.

Abstract

The genus Enterovirus, a member of the Picornavirus family, are RNA viruses that can cause poliomyelitis, hand-food-mouth disease, viral meningitis or meningoencephalitis, viral myocarditis and so on. MicroRNAs are a class of highly conserved, small noncoding RNAs recognized as important regulators of gene expression. Recent studies found that MicroRNAs play a significant role in the infection of Enterovirus, such as enterovirus 71, coxsackievirus B3 and other Enterovirus. Enteroviral infection can alter the expression of cellular MicroRNAs, and cellular MicroRNAs can modulate viral pathogenesis and replication by regulating the expression level of viral or host's genes. Herein, this review summarizes the role of MicroRNAs in enteroviral infection.

Keywords: Enterovirus; Infection; MicroRNAs.

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