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Review
. 2015 Sep 7:21:183-90.
doi: 10.12659/MSMBR.895418.

Past and Present of Total Artificial Heart Therapy: A Success Story

Mostafa Samak  1 , Javid Fatullayev  1 , Anton Sabashnikov  1 , Mohamed Zeriouh  1 , Parwis B Rahmanian  1 , Yeong-Hoon Choi  1 , Jens Wippermann  1 , Thorsten Wahlers  1 , Bastian Schmack  2 , Arjang Ruhparwar  2 , Pascal M Dohmen  3 , Matthias Karck  2 , Aron-Frederik Popov  4 , André R Simon  4 , Alexander Weymann  4
Affiliations
Review

Past and Present of Total Artificial Heart Therapy: A Success Story

Mostafa Samak et al. Med Sci Monit Basic Res. .

Abstract

The totally artificial heart (TAH) is among the most prominent medical innovations of the 21st century, especially due to the increasing population with end-stage heart failure. The progressive course of the disease, its resistance to conventional therapy, and the scarcity of hearts available for transplantation were the prime impetus for developing a TAH, especially when other options of mechanical circulatory assist devices are exhausted. In this review, we narrate the history of TAH, give an overview of its technology, and address the pros and cons of the currently available TAH models in light of published clinical experience.

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Figures

Figure 1
Figure 1
Intraoperative picture demonstrating the situs after excising the mitral and tricuspid valves, including all leaflet tissue, chordae, and subvalvular apparatus. The atrial connectors are double-sutured to the atrial cuffs, while care is taken not to bite deeply into the atria, so as to preserve as much healthy tissue as possible from scaring, especially near the left pulmonary veins.
Figure 2
Figure 2
Intraoperative image showing the ventricular chambers positioned and connected in the chest.
Figure 3
Figure 3
The TAH is appropriately wrapped and adequately positioned in the pericardium to prevent adhesions, which might complicate future transplantation.
See this image and copyright information in PMC

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