Gut Microbiota Dysbiosis in Obesity-Linked Metabolic Diseases and Prebiotic Potential of Polyphenol-Rich Extracts

doi:10.1007/s13679-015-0172-9

Review

. 2015 Dec;4(4):389-400.

doi: 10.1007/s13679-015-0172-9.

Gut Microbiota Dysbiosis in Obesity-Linked Metabolic Diseases and Prebiotic Potential of Polyphenol-Rich Extracts

Fernando F Anhê^{1

2

3}, Thibault V Varin⁴, Mélanie Le Barz^{5

6

7}, Yves Desjardins⁸, Emile Levy^{9

10

11}, Denis Roy¹², André Marette^{13

14

15}

Affiliations

¹ Department of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung Institute, Laval University, Quebec, Canada. fernando.forato@criucpq.ulaval.ca.
² Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 boulevard Hochelaga, Québec, QC, G1V 0A6, Canada. fernando.forato@criucpq.ulaval.ca.
³ Hôpital Laval, Pavillon Marguerite d'Youville, Quebec, QC, G1V 4G5, Canada. fernando.forato@criucpq.ulaval.ca.
⁴ Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 boulevard Hochelaga, Québec, QC, G1V 0A6, Canada. thibaut.varin.1@ulaval.ca.
⁵ Department of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung Institute, Laval University, Quebec, Canada. melanie.lebarz@criucpq.ulaval.ca.
⁶ Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 boulevard Hochelaga, Québec, QC, G1V 0A6, Canada. melanie.lebarz@criucpq.ulaval.ca.
⁷ Hôpital Laval, Pavillon Marguerite d'Youville, Quebec, QC, G1V 4G5, Canada. melanie.lebarz@criucpq.ulaval.ca.
⁸ Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 boulevard Hochelaga, Québec, QC, G1V 0A6, Canada. yves.desjardins@fsaa.ulaval.ca.
⁹ Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 boulevard Hochelaga, Québec, QC, G1V 0A6, Canada. emile.levy@recherche-ste-justine.qc.ca.
¹⁰ Research Centre, CHU-Sainte-Justine and Department of Nutrition, Université de Montréal, 3175, Chemin de la Côte Ste Catherine, bureau 5731A, Montreal, QC, H3T 1C5, Canada. emile.levy@recherche-ste-justine.qc.ca.
¹¹ Department of Nutrition, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada. emile.levy@recherche-ste-justine.qc.ca.
¹² Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 boulevard Hochelaga, Québec, QC, G1V 0A6, Canada. denis.roy@inaf.ulaval.ca.
¹³ Department of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung Institute, Laval University, Quebec, Canada. andre.marette@criucpq.ulaval.ca.
¹⁴ Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 boulevard Hochelaga, Québec, QC, G1V 0A6, Canada. andre.marette@criucpq.ulaval.ca.
¹⁵ Hôpital Laval, Pavillon Marguerite d'Youville, Quebec, QC, G1V 4G5, Canada. andre.marette@criucpq.ulaval.ca.

PMID: 26343880
DOI: 10.1007/s13679-015-0172-9

Review

Gut Microbiota Dysbiosis in Obesity-Linked Metabolic Diseases and Prebiotic Potential of Polyphenol-Rich Extracts

Fernando F Anhê et al. Curr Obes Rep. 2015 Dec.

. 2015 Dec;4(4):389-400.

doi: 10.1007/s13679-015-0172-9.

Authors

Fernando F Anhê^{1

2

3}, Thibault V Varin⁴, Mélanie Le Barz^{5

6

7}, Yves Desjardins⁸, Emile Levy^{9

10

11}, Denis Roy¹², André Marette^{13

14

15}

Affiliations

¹ Department of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung Institute, Laval University, Quebec, Canada. fernando.forato@criucpq.ulaval.ca.
² Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 boulevard Hochelaga, Québec, QC, G1V 0A6, Canada. fernando.forato@criucpq.ulaval.ca.
³ Hôpital Laval, Pavillon Marguerite d'Youville, Quebec, QC, G1V 4G5, Canada. fernando.forato@criucpq.ulaval.ca.
⁴ Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 boulevard Hochelaga, Québec, QC, G1V 0A6, Canada. thibaut.varin.1@ulaval.ca.
⁵ Department of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung Institute, Laval University, Quebec, Canada. melanie.lebarz@criucpq.ulaval.ca.
⁶ Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 boulevard Hochelaga, Québec, QC, G1V 0A6, Canada. melanie.lebarz@criucpq.ulaval.ca.
⁷ Hôpital Laval, Pavillon Marguerite d'Youville, Quebec, QC, G1V 4G5, Canada. melanie.lebarz@criucpq.ulaval.ca.
⁸ Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 boulevard Hochelaga, Québec, QC, G1V 0A6, Canada. yves.desjardins@fsaa.ulaval.ca.
⁹ Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 boulevard Hochelaga, Québec, QC, G1V 0A6, Canada. emile.levy@recherche-ste-justine.qc.ca.
¹⁰ Research Centre, CHU-Sainte-Justine and Department of Nutrition, Université de Montréal, 3175, Chemin de la Côte Ste Catherine, bureau 5731A, Montreal, QC, H3T 1C5, Canada. emile.levy@recherche-ste-justine.qc.ca.
¹¹ Department of Nutrition, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada. emile.levy@recherche-ste-justine.qc.ca.
¹² Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 boulevard Hochelaga, Québec, QC, G1V 0A6, Canada. denis.roy@inaf.ulaval.ca.
¹³ Department of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung Institute, Laval University, Quebec, Canada. andre.marette@criucpq.ulaval.ca.
¹⁴ Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 boulevard Hochelaga, Québec, QC, G1V 0A6, Canada. andre.marette@criucpq.ulaval.ca.
¹⁵ Hôpital Laval, Pavillon Marguerite d'Youville, Quebec, QC, G1V 4G5, Canada. andre.marette@criucpq.ulaval.ca.

PMID: 26343880
DOI: 10.1007/s13679-015-0172-9

Abstract

Trillions of microorganisms inhabit the human body, strongly colonizing the gastro-intestinal tract and outnumbering our own cells. High-throughput sequencing techniques and new bioinformatic tools have enabled scientists to extend our knowledge on the relationship between the gut microbiota and host's physiology. Disruption of the ecological equilibrium in the gut (i.e., dysbiosis) has been associated with several pathological processes, including obesity and its related comorbidities, with diet being a strong determinant of gut microbial balance. In this review, we discuss the potential prebiotic effect of polyphenol-rich foods and extracts and how they can reshape the gut microbiota, emphasizing the novel role of the mucin-degrading bacterium Akkermansia muciniphila in their metabolic benefits.

Keywords: Akkermansia; Insulin resistance; Obesity; Polyphenols; Prebiotics.

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References

1. J Physiol. 2009 Sep 1;587(Pt 17):4153-8 - PubMed
1. Nature. 2013 Dec 19;504(7480):446-50 - PubMed
1. Eur J Nutr. 2015 Apr;54(3):325-41 - PubMed
1. Asia Pac J Clin Nutr. 2012;21(4):601-8 - PubMed
1. Nature. 2015 Mar 5;519(7541):92-6 - PubMed

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[1] J Physiol. 2009 Sep 1;587(Pt 17):4153-8 - PubMed

[2] J Physiol. 2009 Sep 1;587(Pt 17):4153-8 - PubMed

[3] Nature. 2013 Dec 19;504(7480):446-50 - PubMed

[4] Nature. 2013 Dec 19;504(7480):446-50 - PubMed

[5] Eur J Nutr. 2015 Apr;54(3):325-41 - PubMed

[6] Eur J Nutr. 2015 Apr;54(3):325-41 - PubMed

[7] Asia Pac J Clin Nutr. 2012;21(4):601-8 - PubMed

[8] Asia Pac J Clin Nutr. 2012;21(4):601-8 - PubMed

[9] Nature. 2015 Mar 5;519(7541):92-6 - PubMed

[10] Nature. 2015 Mar 5;519(7541):92-6 - PubMed

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Gut Microbiota Dysbiosis in Obesity-Linked Metabolic Diseases and Prebiotic Potential of Polyphenol-Rich Extracts

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Gut Microbiota Dysbiosis in Obesity-Linked Metabolic Diseases and Prebiotic Potential of Polyphenol-Rich Extracts

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