Multifunctional quantum dots-based cancer diagnostics and stem cell therapeutics for regenerative medicine

Daisuke Onoshima¹, Hiroshi Yukawa², Yoshinobu Baba³

Affiliations

¹ Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan. Electronic address: onoshima-d@nanobio.nagoya-u.ac.jp.
² ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan. Electronic address: hiroshiy@med.nagoya-u.ac.jp.
³ Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14, Hayashi-cho, Takamatsu 761-0395, Japan.

PMID: 26344675
DOI: 10.1016/j.addr.2015.08.004

Review

Multifunctional quantum dots-based cancer diagnostics and stem cell therapeutics for regenerative medicine

Daisuke Onoshima et al. Adv Drug Deliv Rev. 2015.

. 2015 Dec 1:95:2-14.

doi: 10.1016/j.addr.2015.08.004. Epub 2015 Sep 4.

Authors

Daisuke Onoshima¹, Hiroshi Yukawa², Yoshinobu Baba³

Affiliations

¹ Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan. Electronic address: onoshima-d@nanobio.nagoya-u.ac.jp.
² ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan. Electronic address: hiroshiy@med.nagoya-u.ac.jp.
³ Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14, Hayashi-cho, Takamatsu 761-0395, Japan.

PMID: 26344675
DOI: 10.1016/j.addr.2015.08.004

Abstract

A field of recent diagnostics and therapeutics has been advanced with quantum dots (QDs). QDs have developed into new formats of biomolecular sensing to push the limits of detection in biology and medicine. QDs can be also utilized as bio-probes or labels for biological imaging of living cells and tissues. More recently, QDs has been demonstrated to construct a multifunctional nanoplatform, where the QDs serve not only as an imaging agent, but also a nanoscaffold for diagnostic and therapeutic modalities. This review highlights the promising applications of multi-functionalized QDs as advanced nanosensors for diagnosing cancer and as innovative fluorescence probes for in vitro or in vivo stem cell imaging in regenerative medicine.

Keywords: Cancer diagnosis; Cationic liposomes; Cell transplantation; Cell-penetrating peptides; FRET; Microfluidic device; Quantum dots; Stem cell labeling.

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Multifunctional quantum dots-based cancer diagnostics and stem cell therapeutics for regenerative medicine

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Multifunctional quantum dots-based cancer diagnostics and stem cell therapeutics for regenerative medicine

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