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. 2015:2015:839697.
doi: 10.1155/2015/839697. Epub 2015 Aug 4.

Immunoregulation on Mice of Low Immunity and Effects on Five Kinds of Human Cancer Cells of Panax japonicus Polysaccharide

Zhang Jie  1 , Li Chun-Yan  2 , Li Jing-Ping  3 , Guo Ren  1 , Wang Hui  4 , Pan Juan  5 , Liu Sheng-Lan  1
Affiliations

Immunoregulation on Mice of Low Immunity and Effects on Five Kinds of Human Cancer Cells of Panax japonicus Polysaccharide

Zhang Jie et al. Evid Based Complement Alternat Med. 2015.

Abstract

The goal of this study is to investigate the immunoregulative effects of Panax japonicus polysaccharide (PJPS) on mice of low immunity. An orthogonal experiment was designed to determine the best extraction process for PJPS. By the tests of macrophages swallow chicken red blood cells, Delayed-type hypersensitivity (DTH), and serum hemolysin value, we studied the immune adjustment ability of PJPS. MTT was employed to detect the effects of different concentrations of PJPS, respectively, in 24 h, 48 h, and 72 h on five kinds of human cancer cells. The results show that the best extraction process for PJPS was as follows: ratio of solvent consumption to raw material 40, extraction temperature 100°C, re-extracted two times, each extraction time 4 hours. PJPS can significantly improve the immune function of mice processed by cyclophosphamide and PJPS did not work on the above five cancer cells.

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Figures

Figure 1
Figure 1
Macrophages adsorbed multiple chicken red blood cells.
Figure 2
Figure 2
Macrophages swallowed multiple chicken red blood cells.
Figure 3
Figure 3
Macrophages adsorbed and swallowed multiple chicken red blood cells.
See this image and copyright information in PMC

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