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. 2015:2015:127516.
doi: 10.1155/2015/127516. Epub 2015 Aug 4.

Metastasis of Gastric Signet-Ring Cell Carcinoma to the Urinary Bladder: A Case Report and Review of the Literature

Kerem Okutur  1 , Orhan Onder Eren  2 , Gokhan Demir  1
Affiliations

Metastasis of Gastric Signet-Ring Cell Carcinoma to the Urinary Bladder: A Case Report and Review of the Literature

Kerem Okutur et al. Case Rep Oncol Med. 2015.

Abstract

Although signet-ring cell (SRC) adenocarcinoma is commonly seen in the stomach, it is a very rarely seen histologic entity in the bladder. It is difficult to distinguish primary SRC adenocarcinoma of the bladder from bladder metastasis of SRC carcinoma of the stomach only based on histological findings. In such cases, clinical findings and immunohistochemical studies may be helpful. We present here a 48-year-old male patient presenting with hematuria and abdominal pain. Computerised tomography of the patient revealed a gastric mass, peritoneal involvement, and thickening of the bladder wall, and histopathological analysis revealed SRC adenocarcinoma in both of the endoscopic biopsies taken from the stomach and bladder. Immunohistochemical analyses confirmed the diagnosis of SRC adenocarcinoma of the bladder secondary to gastric cancer.

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Figures

Figure 1
Figure 1
Primary signet-ring cell (arrow) carcinoma of the stomach (H&E, ×20).
Figure 2
Figure 2
Signet-ring cell carcinoma infiltrating bladder subepithelium (H&E, ×20).
See this image and copyright information in PMC

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