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. 2015:2015:714919.
doi: 10.1155/2015/714919. Epub 2015 Aug 6.

From Eye Drops to ICU, a Case Report of Three Side Effects of Ophthalmic Timolol Maleate in the Same Patient

Muhammad Asim Rana  1 , Ahmed Fouad Mady  2 , Basheer Abdel Rehman  2 , Abdulrahman Alharthy  2 , Basim Huwait  2 , Asim Riaz  1 , Waleed Tharwat Aletreby  2
Affiliations

From Eye Drops to ICU, a Case Report of Three Side Effects of Ophthalmic Timolol Maleate in the Same Patient

Muhammad Asim Rana et al. Case Rep Crit Care. 2015.

Abstract

Timolol Maleate (also called Timolol) is a nonselective beta-adrenergic blocker and a class II antiarrhythmic drug, which is used to treat intraocular hypertension. It has been reported to cause systemic side effects especially in elderly patients with other comorbidities. These side effects are due to systemic absorption of the drug and it is known that Timolol is measurable in the serum following ophthalmic use. Chances of life threatening side effects increase if these are coprescribed with other cardiodepressant drugs like calcium channel or systemic beta blockers. We report a case where an elderly patient was admitted with three side effects of Timolol and his condition required ICU admission with mechanical ventilation and temporary transvenous pacing. The case emphasizes the need of raising awareness among physicians of such medications about the potential side effects and drug interactions. A close liaison among patient's physicians is suggested.

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Figures

Figure 1
Figure 1
ECG showing sinus bradycardia.
Figure 2
Figure 2
ECG with sinus dysfunction and Mobitz 1 block.
See this image and copyright information in PMC

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