Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015:2015:259074.
doi: 10.1155/2015/259074. Epub 2015 Aug 4.

Relationship between Periodontitis and Rheumatoid Arthritis: Review of the Literature

Vilana Maria Adriano Araújo  1 , Iracema Matos Melo  2 , Vilma Lima  1
Affiliations
Review

Relationship between Periodontitis and Rheumatoid Arthritis: Review of the Literature

Vilana Maria Adriano Araújo et al. Mediators Inflamm. 2015.

Abstract

Periodontitis (PD) and rheumatoid arthritis (RA) are immunoinflammatory diseases where leukocyte infiltration and inflammatory mediators induce alveolar bone loss, synovitis, and joint destruction, respectively. Thus, we reviewed the relationship between both diseases considering epidemiological aspects, mechanical periodontal treatment, inflammatory mediators, oral microbiota, and antibodies, using the keywords "periodontitis" and "rheumatoid arthritis" in PubMed database between January 2012 and March 2015, resulting in 162 articles. After critical reading based on titles and abstracts and following the inclusion and exclusion criteria, 26 articles were included. In the articles, women over 40 years old, smokers and nonsmokers, mainly constituted the analyzed groups. Eight studies broached the epidemiological relationship with PD and RA. Four trials demonstrated that the periodontal treatment influenced the severity of RA and periodontal clinical parameters. Nine studies were related with bacteria influence in the pathogenesis of RA and the presence of citrullinated proteins, autoantibodies, or rheumatoid factor in patients with PD and RA. Five studies investigated the presence of mediators of inflammation in PD and RA. In summary, the majority of the articles have confirmed that there is a correlation between PD and RA, since both disorders have characteristics in common and result from an imbalance in the immunoinflammatory response.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Scheme on the relationship between periodontitis and rheumatoid arthritis. (a) Pathogenesis of periodontitis and the effects promoted by lipopolysaccharides present in periodontopathogens. (b) The involvement of genetic and environmental factors in the development of rheumatoid arthritis. (c) Possible mechanisms that explain the relationship between rheumatoid arthritis and periodontitis.
Figure 2
Figure 2
Search flow-chart and selection of articles for the review of the literature considering a bit more than the last three years. PD = periodontitis; RA = rheumatoid arthritis.
See this image and copyright information in PMC

References

    1. Yucel-Lindberg T., Båge T. Inflammatory mediators in the pathogenesis of periodontitis. Expert Reviews in Molecular Medicine. 2013;15, article e7:1–13. doi: 10.1017/erm.2013.8. - DOI - PubMed
    1. Belibasakis G. N., Reddi D., Bostanci N. Porphyromonas gingivalis induces RANKL in T-cells. Inflammation. 2011;34(2):133–138. doi: 10.1007/s10753-010-9216-1. - DOI - PubMed
    1. Stabholz A., Soskolne W. A., Shapira L. Genetic and environmental risk factors for chronic periodontitis and aggressive periodontitis. Periodontology 2000. 2010;53(1):138–153. doi: 10.1111/j.1600-0757.2010.00340.x. - DOI - PubMed
    1. Genco R. J., Borgnakke W. S. Risk factors for periodontal disease. Periodontology 2000. 2013;62(1):59–94. doi: 10.1111/j.1600-0757.2012.00457.x. - DOI - PubMed
    1. Loos B. G., John R. P., Laine M. L. Identification of genetic risk factors for periodontitis and possible mechanisms of action. Journal of Clinical Periodontology. 2005;32(supplement 6):159–179. doi: 10.1111/j.1600-051x.2005.00806.x. - DOI - PubMed

Substances

LinkOut - more resources