Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015:2015:465450.
doi: 10.1155/2015/465450. Epub 2015 Aug 12.

Osseous Metaplasia in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney: A Case of Massive, Bilateral Tumors

Aeen M Asghar  1 , Matthew A Uhlman  2 , Laila Dahmoush  3 , Sundeep Deorah  2
Affiliations

Osseous Metaplasia in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney: A Case of Massive, Bilateral Tumors

Aeen M Asghar et al. Case Rep Urol. 2015.

Abstract

Renal cell carcinoma (RCC) is the most common kidney malignancy, with many histologic subtypes. One of the rare forms of RCC is mucinous tubular and spindle cell carcinoma (MTSCC), which is newly described with limited information on clinical picture and outcome. Heterotopic bone formation (osseous metaplasia) is a rare finding within any renal mass. Here we report a case of a massive, bilateral MTSCC with histologic findings of heterotopic bone formation, which has not been described before.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Preoperative abdominal MRI.
Figure 2
Figure 2
Gross left kidney with mucinous tubular and spindle cell carcinoma.
Figure 3
Figure 3
Tumor cells forming merging tubules containing mucin.
Figure 4
Figure 4
Tumor cells showing spindle cell morphology at the center.
Figure 5
Figure 5
Bone trabeculae are seen adjacent to tumor cells.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Siegel R., Naishadham D., Jemal A. Cancer statistics, 2013. CA—Cancer Journal for Clinicians. 2013;63(1):11–30. doi: 10.3322/caac.21166. - DOI - PubMed
    1. Srigley J. R., Delahunt B., Eble J. N., et al. The International Society of Urological Pathology (ISUP) Vancouver classification of renal neoplasia. The American Journal of Surgical Pathology. 2013;37(10):1469­–1489. - PubMed
    1. Daniel W. W., Jr., Hartman G. W., Witten D. M., Farrow G. M., Kelalis P. P. Calcified renal masses. A review of ten years experience at the Mayo Clinic. Radiology. 1972;103(3):503–508. doi: 10.1148/103.3.503. - DOI - PubMed
    1. Fine S. W., Argani P., DeMarzo A. M., et al. Expanding the histologic spectrum of mucinous tubular and spindle cell carcinoma of the kidney. The American Journal of Surgical Pathology. 2006;30(12):1554–1560. doi: 10.1097/01.pas.0000213271.15221.e3. - DOI - PubMed
    1. Hussain M., Din N. U., Azam M., Loya A. Mucinous tubular and spindle cell carcinoma of kidney: a clinicopathologic study of six cases. Indian Journal of Pathology and Microbiology. 2012;55(4):439–442. doi: 10.4103/0377-4929.107776. - DOI - PubMed

LinkOut - more resources