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Randomized Controlled Trial
. 2015:2015:798460.
doi: 10.1155/2015/798460. Epub 2015 Aug 18.

Can the Onset of Type 2 Diabetes Be Delayed by a Group-Based Lifestyle Intervention in Women with Prediabetes following Gestational Diabetes Mellitus (GDM)? Findings from a Randomized Control Mixed Methods Trial

Angela O'Dea  1 , Marie Tierney  1 , Brian E McGuire  2 , John Newell  3 , Liam G Glynn  4 , Irene Gibson  5 , Eoin Noctor  1 , Andrii Danyliv  6 , Susan B Connolly  7 , Fidelma P Dunne  1
Affiliations
Randomized Controlled Trial

Can the Onset of Type 2 Diabetes Be Delayed by a Group-Based Lifestyle Intervention in Women with Prediabetes following Gestational Diabetes Mellitus (GDM)? Findings from a Randomized Control Mixed Methods Trial

Angela O'Dea et al. J Diabetes Res. 2015.

Abstract

Objective: To evaluate a 12-week group-based lifestyle intervention programme for women with prediabetes following gestational diabetes (GDM).

Design: A two-group, mixed methods randomized controlled trial in which 50 women with a history of GDM and abnormal glucose tolerance postpartum were randomly assigned to intervention (n = 24) or wait control (n = 26) and postintervention qualitative interviews with participants.

Main outcome measures: Modifiable biochemical, anthropometric, behavioural, and psychosocial risk factors associated with the development of type 2 diabetes. The primary outcome variable was the change in fasting plasma glucose (FPG) from study entry to one-year follow-up.

Results: At one-year follow-up, the intervention group showed significant improvements over the wait control group on stress, diet self-efficacy, and quality of life. There was no evidence of an effect of the intervention on measures of biochemistry or anthropometry; the effect on one health behaviour, diet adherence, was close to significance.

Conclusions: Prevention programmes must tackle the barriers to participation faced by this population; home-based interventions should be investigated. Strategies for promoting long-term health self-management need to be developed and tested.

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Figures

Figure 1
Figure 1
Consort flow diagram showing flow of participants through the trial.
Figure 2
Figure 2
Boxplot of baseline glucose tolerance (2-hour) (GT2h) per group.
See this image and copyright information in PMC

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