Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Aug 5;3(3):620-37.
doi: 10.3390/vaccines3030620.

Plant Viruses as Nanoparticle-Based Vaccines and Adjuvants

Marie-Ève Lebel  1 , Karine Chartrand  2 , Denis Leclerc  3 , Alain Lamarre  4
Affiliations
Review

Plant Viruses as Nanoparticle-Based Vaccines and Adjuvants

Marie-Ève Lebel et al. Vaccines (Basel). .

Abstract

Vaccines are considered one of the greatest medical achievements in the battle against infectious diseases. However, the intractability of various diseases such as hepatitis C, HIV/AIDS, malaria, tuberculosis, and cancer poses persistent hurdles given that traditional vaccine-development methods have proven to be ineffective; as such, these challenges have driven the emergence of novel vaccine design approaches. In this regard, much effort has been put into the development of new safe adjuvants and vaccine platforms. Of particular interest, the utilization of plant virus-like nanoparticles and recombinant plant viruses has gained increasing significance as an effective tool in the development of novel vaccines against infectious diseases and cancer. The present review summarizes recent advances in the use of plant viruses as nanoparticle-based vaccines and adjuvants and their mechanism of action. Harnessing plant-virus immunogenic properties will enable the design of novel, safe, and efficacious prophylactic and therapeutic vaccines against disease.

Keywords: adjuvant; immune response; production methods; recombinant plant virus; vaccine.

PubMed Disclaimer

References

    1. Imai T., Ishida H., Suzue K., Taniguchi T., Okada H., Shimokawa C., Hisaeda H. Cytotoxic activities of CD8+ T cells collaborate with macrophages to protect against blood-stage murine malaria. Elife. 2015 doi: 10.7554/eLife.04232. - DOI - PMC - PubMed
    1. Barth H., Rybczynska J., Patient R., Choi Y., Sapp R.K., Baumert T.F., Krawczynski K., Liang T.J. Both innate and adaptive immunity mediate protective immunity against hepatitis C virus infection in chimpanzees. Hepatology. 2011;54:1135–1148. doi: 10.1002/hep.24489. - DOI - PMC - PubMed
    1. Holz L., Rehermann B. T cell responses in hepatitis C virus infection: Historical overview and goals for future research. Antivir. Res. 2015;114:96–105. doi: 10.1016/j.antiviral.2014.11.009. - DOI - PMC - PubMed
    1. Pereyra F., Heckerman D., Carlson J.M., Kadie C., Soghoian D.Z., Karel D., Goldenthal A., Davis O.B., de Ziel C.E., Lin T., et al. Hiv control is mediated in part by CD8+ T-cell targeting of specific epitopes. J. Virol. 2014;88:12937–12948. doi: 10.1128/JVI.01004-14. - DOI - PMC - PubMed
    1. De Souza J.B. Protective immunity against malaria after vaccination. Parasite Immunol. 2014;36:131–139. doi: 10.1111/pim.12086. - DOI - PubMed

LinkOut - more resources