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Case Reports
. 2015 Jul 18;9(2):241-5.
doi: 10.1159/000437293. eCollection 2015 May-Aug.

Mixed Adenoneuroendocrine Carcinoma of the Stomach

Ching-Ming Kwok  1
Affiliations
Case Reports

Mixed Adenoneuroendocrine Carcinoma of the Stomach

Ching-Ming Kwok. Case Rep Gastroenterol. .

Abstract

Mixed adenoneuroendocrine carcinoma is a rare condition comprising at least 30%percnt; of each component of exocrine and endocrine tumors. The denominations were defined in the 2000 WHO classification of endocrine tumors. We report an 83-year-old male with a polypoid gastric tumor in the gastric high body who received total gastrectomy and died 8 months after the diagnosis from local recurrence and distal metastases. A review of the literature for this infrequent condition is presented.

Keywords: Adenoneuroendocrine carcinoma; Gastric cancer; MANECs.

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Figures

Fig. 1
Fig. 1
Computed tomography showed a focal polypoid lesion (4.5 × 3.6 cm) in the gastric high body region protruding into the lumen nearby the esophagogastric junction (arrow) with adjacent lymph node enlargement.
Fig. 2
Fig. 2
A 5-cm tumor in the posterior wall of the high body (arrow). The tumor protruded into the stomach lumen with wall thickening of the gastric wall, located near the esophagogastric junction.
Fig. 3
Fig. 3
Schematic representation showing the wide spectrum of combinations of exocrine and neuroendocrine components in human tumors, ranging from neuroendocrine neoplasms with a focal exocrine component at one extreme (left) to exocrine carcinomas with interspersed neuroendocrine cells at the other (right). However, mixed exocrine-neuroendocrine tumors (middle) are only those neoplasms in which each component represents at least 30%percnt; of the lesion. NE = Neuroendocrine; tum. = tumor; ca. = carcinoma. Modified from Volante et al. [5].
See this image and copyright information in PMC

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